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Methylenetetrahydrofolate reductase gene C677T mutation and plasma homocysteine level in Behçet's disease



Methylenetetrahydrofolate reductase gene C677T mutation and plasma homocysteine level in Behçet's disease



Rheumatology International 23(5): 236-240



Objective: The aim of this study was to assess whether homozygosity for the 5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T mutation and plasma homocysteine concentration are related to deep vein thrombosis in Behcet's disease (BD) patients. Methods: Forty BD patients (23 males, 17 females; mean age 40.2+-8.4 years) and 60 healthy controls (HC) (34 males, 26 females; mean age 41.6+-6.9 years) were included in the study. Fourteen of the BD patients had a history of deep venous thrombosis (DVT), as confirmed by Doppler ultrasound. Results: The rates of homozygosity for the MTHFR C677T mutation in the BD and HC groups were 7.5% and 10%, respectively. The distribution of MTHFR genotypes was similar in the two groups (p>0.05), and analysis showed that homozygosity for the mutation was not a risk factor for DVT. The mean plasma homocysteine levels were 13.4+-4.2 mumol/l for the overall BD patients and 12.6+-3.8 mumol/l for HC (p>0.05). However, the mean plasma homocysteine level in the BD patients with DVT history (15.9+-4.6 mumol/l) was significantly higher than the level in the BD patients with no DVT history (12.1+-3.3 mumol/l) (p=0.013) and the level in the HC group (12.6+-3.8 mumol/l) (p=0.025). Conclusion: The study results suggest that elevated plasma homocysteine level may play a role in the pathogenesis of venous thrombosis in BD.

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Accession: 049585620

Download citation: RISBibTeXText

PMID: 14504916

DOI: 10.1007/s00296-003-0301-8


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