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Mutant nicastrin protein can induce the cytochrome c release and the Bax expression

Hwang, D.Y.; Kim, Y.K.; Lim, C.J.; Cho, J.S.

International Journal of Neuroscience 114(10): 1277-1289

2004


ISSN/ISBN: 0020-7454
PMID: 15370186
DOI: 10.1080/00207450490476048
Accession: 049643846

This study investigated whether nicastrin can induce apoptotic cell death in SK-N-MC cells. MTT assays revealed the transfected cells expressing mutant nicastrin, compared with those expressing wild nicastrin or the control vector, showing significantly increased cell death. The mutant nicastrin transfectants were also observed to induce cytosolic cytochrome c release from the mitochondria, and Bax protein expression in response, to increased cell death. These observations suggested that nicastrin, as well as the APP and PS proteins, were also involved in the upregulated Bax mediated neuroblastoma cell death and the release of cytochrome c in the neuroblastoma.

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