+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling

NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling

Molecular and Cellular Biology 26(8): 2936-2946

Synaptic activity-dependent de novo gene transcription is crucial for long-lasting neuronal plasticity and long-term memory. In a forebrain neuronal conditional NF-kappaB-deficient mouse model, we demonstrate here that the transcription factor NF-kappaB regulates spatial memory formation, synaptic transmission, and plasticity. Gene profiling experiments and analysis of regulatory regions identified the alpha catalytic subunit of protein kinase A (PKA), an essential memory regulator, as a new NF-kappaB target gene. Consequently, NF-kappaB inhibition led to a decrease in forskolin-induced CREB phosphorylation. Collectively, these results disclose a novel hierarchical transcriptional network involving NF-kappaB, PKA, and CREB that leads to concerted nuclear transduction of synaptic signals in neurons, accounting for the critical function of NF-kappaB in learning and memory.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 049652578

Download citation: RISBibTeXText

PMID: 16581769

DOI: 10.1128/MCB.26.8.2936-2946.2006

Related references

NF-kB Regulates Spatial Memory Formation and Synaptic Plasticity through Protein Kinase A/CREB Signaling. Molecular and Cellular Biology 26(8): 36-46, 2006

The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory. Eneuro 4(1), 2018

Protein kinase signaling in synaptic plasticity and memory. Current Opinion in Neurobiology 17(3): 313-317, 2007

Focal adhesion kinase regulates neuronal growth, synaptic plasticity and hippocampus-dependent spatial learning and memory. Neuro-Signals 20(1): 1-14, 2012

The NO-cGMP-PKG signaling pathway regulates synaptic plasticity and fear memory consolidation in the lateral amygdala via activation of ERK/MAP kinase. Learning and Memory 15(10): 792-805, 2008

LIMK1 regulates long-term memory and synaptic plasticity via the transcriptional factor CREB. Molecular and Cellular Biology 35(8): 1316-1328, 2015

Reversal of synaptic plasticity and spatial memory deficits in APP/PS1 mice by suppressing protein kinase GCN2. Alzheimer's & Dementia 9(4): P519-P520, 2013

Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory. Journal of Neuroscience 32(50): 18137-18149, 2013

Phosphoprotein regulation of memory formation: enhancement and control of synaptic plasticity by protein kinase C and protein F1. Annals of the New York Academy of Sciences 444: 203-211, 1985

Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice. Journal of Neurochemistry 104(3): 611-623, 2007

Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex. Neuropharmacology 44(1): 40-48, 2003

Electroacupuncture Ameliorates Learning and Memory and Improves Synaptic Plasticity via Activation of the PKA/CREB Signaling Pathway in Cerebral Hypoperfusion. Evidence-Based Complementary and Alternative Medicine 2016: 7893710, 2016

Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease. Journal of Neuroscience 35(41): 14042-14056, 2016

PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates Vascular Smooth Muscle Cell Phenotypic Modulation and Neointimal Formation Through CREB (Cyclic AMP-Response Element Binding Protein)/YAP (Yes-Associated Protein) Signaling. Arteriosclerosis, Thrombosis, and Vascular Biology 2019: Atvbaha118312212, 2019

CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models. Trends in Neurosciences 33(5): 230-240, 2010