+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neurobiology of stress urinary incontinence: new insights and implications for treatment



Neurobiology of stress urinary incontinence: new insights and implications for treatment



Journal of Obstetrics and Gynaecology 25(6): 539-543



Stress urinary incontinence (SUI) is a significant problem for millions of women, many of whom remain untreated for years, sometimes for life. One reason for this is the lack of effective pharmacologic therapy. The drugs used for urge incontinence have little or no effect on leakage occurring without detrusor contraction under conditions of increased intra-abdominal pressure. Recent studies suggest that extrinsic urethral sphincter closure may be controlled by enhancing neurotransmission in pudendal pathways. A new agent, duloxetine, which inhibits serotonin-norepinephrine re-uptake in these pathways, is now in clinical trials and appears to be the first effective pharmacologic therapy for SUI.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 049670566

Download citation: RISBibTeXText

PMID: 16234136

DOI: 10.1080/01443610500227961


Related references

Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction. Journal of Urology 174(5): 2041-2045, 2005

Regeneration of urinary stress incontinence--application to treatment of intractable urinary stress incontinence of advanced age--. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 50(3): 362-365, 2013

The pathophysiology of stress urinary incontinence in women and its implications for surgical treatment. World Journal of Urology 15(5): 268-274, 1997

The questionnaire for urinary incontinence diagnosis (QUID): validity and responsiveness to change in women undergoing non-surgical therapies for treatment of stress predominant urinary incontinence. Neurourology and Urodynamics 29(5): 727-734, 2010

Sonic hedgehog regulation of human rhabdosphincter muscle:Potential implications for treatment of stress urinary incontinence. Neurourology and Urodynamics 37(8): 2551-2559, 2018

Associated factors and the impact of fecal incontinence in women with urge urinary incontinence: from the Urinary Incontinence Treatment Network's Behavior Enhances Drug Reduction of Incontinence study. American Journal of Obstetrics and Gynecology 200(4): 424.E1-8, 2009

The minimum important difference for the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form in women with stress urinary incontinence. Neurourology and Urodynamics 34(2): 183-187, 2015

Comparative data from history, clinical examination and urodynamics in patients with genuine stress urinary incontinence and recurrent stress urinary incontinence after surgery. International Urogynecology Journal 1(4): 206-211, 1990

The changes of voiding pattern after midurethral sling between pure stress urinary incontinence and stress urinary incontinence with overactive bladder group. Korean Journal of Urology 55(6): 400-404, 2014

Efficacy and safety of duloxetine in elderly women with stress urinary incontinence or stress-predominant mixed urinary incontinence. Maturitas 60(2): 138-147, 2008

Pubo-urethral ligament transection causes stress urinary incontinence in the female rat: a novel animal model of stress urinary incontinence. Journal of Urology 179(2): 775-778, 2008

Urodynamics Before Surgery for Stress Urinary Incontinence: The Urodynamic Examination Is Still One of the Best Friends of the Surgeon and of Patients with Stress Urinary Incontinence. European Urology Focus 2(3): 272-273, 2016

Transobturator adjustable tape for severe stress urinary incontinence and stress urinary incontinence with voiding dysfunction. International Urogynecology Journal 22(3): 341-346, 2011

Treatment of female stress urinary incontinence. Value of classical incontinence operations. Der Urologe. Ausg. a 54(3): 342-348, 2015

Sacral neuromodulation for the treatment of refractory urinary urge incontinence after stress incontinence surgery. American Journal of Obstetrics and Gynecology 193(6): 2083-2087, 2005