+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Oral misoprostol (100 microg) versus vaginal misoprostol (25 microg) in term labor induction: a randomized comparison



Oral misoprostol (100 microg) versus vaginal misoprostol (25 microg) in term labor induction: a randomized comparison



Acta Obstetricia et Gynecologica Scandinavica 82(12): 1103-1106



To compare the efficacy of vaginal misoprostol (25 microg) to oral misoprostol (100 microg) in labor induction at term. One hundred and one women at term, with indications for labor induction and cervical Bishop's scores of less than 8, were randomly assigned to receive 100 microg of oral misoprostol or 25 microg vaginal misoprostol after random allocation. This could be repeated every 4 h to a maximum of five doses. The number delivering vaginally within 24 h of the induction was the main outcome measure. Of those who delivered vaginally (74.5% in the oral group vs. 72% in the vaginal group), significantly fewer women delivered within 24 h of induction in the oral group (42.1% vs. 72.2%, RR 0.6, 95% CI 0.4-0.9), with more women receiving more than one dose (45.7% vs. 16.7%, RR 2.7, 95% CI 1.2-6.0). More women in the oral group received oxytocin (68.6% vs. 44%, RR 1.6, 95% CI 1.1-2.2), and the induction to delivery interval was shorter in the vaginal group, although this was not statistically significant [28.9 h (SD 20.2) vs. 20.6 h (SD 16.1), mean difference - 8.3 h, 95% CI - 16.8 to 0.2]. There were no differences in the modes of delivery, uterine hyperstimulation rates or in the neonatal outcomes. Vaginal misoprostol in its currently recommended dose of 25 microg seems to be more efficacious than the 100 microg oral dose.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 049814667

Download citation: RISBibTeXText

PMID: 14616254


Related references

A comparison between single dose of 50 microg oral misoprostol and 25 microg vaginal misoprostol for labor induction. Journal of the Medical Association of Thailand 88(Suppl. 2): S56-S62, 2005

Labor induction at term: a comparison of the effects of 50 microg and 25 microg vaginal misoprostol. Clinical and Experimental Obstetrics and Gynecology 34(2): 102-105, 2007

A comparison of vaginal misoprostol 800 microg versus 400 microg for anembryonic pregnancy: a randomized comparative trial. Journal of the Medical Association of Thailand 88(Suppl. 2): S41-S47, 2005

A comparison of vaginal misoprostol 800 microg versus 400 microg in early pregnancy failure: a randomized controlled trial. Journal of the Medical Association of Thailand 87(Suppl. 3): S18-S23, 2004

Randomized comparison of vaginal (200 microg every 3 h) and oral (400 microg every 3 h) misoprostol when combined with mifepristone in termination of second trimester pregnancy. Human Reproduction 15(10): 2205-2208, 2000

Labor induction with 25 microg versus 50 microg intravaginal misoprostol: a systematic review. Obstetrics and Gynecology 99(1): 145-151, 2002

Misoprostol 50 microg sublingually versus vaginally for labor induction at term: a randomized study. Gynecologic and Obstetric Investigation 59(3): 155-161, 2005

Pre-induction cervical ripening with 25 microg and 50 microg vaginal misoprostol in 181 nulliparous parturients. Journal of Maternal-Fetal and Neonatal Medicine 22(3): 265-268, 2009

Cervical ripening and labor induction with 25 microg vs. 50 microg of intravaginal misoprostol. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics 90(3): 234-235, 2005

Second-trimester pregnancy termination with 600-microg vs. 400-microg vaginal misoprostol and systematic curettage postexpulsion: a randomized trial. Contraception 77(1): 50-55, 2008

A comparison of 100 microg oral misoprostol every 3 hours and 6 hours for labor induction: a randomized controlled trial. Journal of Obstetrics and Gynaecology Research 28(6): 308-312, 2002

Labor induction with 25-microg misoprostol vaginal capsules. Gynecologic and Obstetric Investigation 68(4): 272-275, 2009

A randomized comparison of one single dose of vaginal 50 microg misoprostol with 3 mg dinoprostone in pre-induction cervical ripening. Journal of the Medical Association of Thailand 83(9): 1026-1034, 2000

Vaginal misoprostol for induction of labor: 25 vs. 50 microg dose regimen. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics 72(1): 25-30, 2001

Comparison Between Use of Oral Misoprostol Versus Vaginal Misoprostol for Induction of Labour at Term. Journal of Obstetrics and Gynaecology of India 68(2): 88-92, 2018