+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Outcome of patients with acute coronary syndromes and moderate coronary lesions undergoing deferral of revascularization based on fractional flow reserve assessment



Outcome of patients with acute coronary syndromes and moderate coronary lesions undergoing deferral of revascularization based on fractional flow reserve assessment



Catheterization and Cardiovascular Interventions 68(4): 544-548



To determine the outcome of consecutive patients with and without acute coronary syndromes (ACS) in whom revascularization was deferred on the basis of fractional flow reserve (FFR). FFR < 0.75 correlates with ischemia on noninvasive tests and deferral of treatment on the basis of FFR is associated with low event rates in selected populations. Whether these low event rates apply to patients undergoing assessment of moderate stenoses in association with an ACS is not known and is an important clinical question. Retrospective analysis and 12 month follow-up of consecutive, moderate (50-70%) de novo coronary lesions assessed with FFR. Revascularization was deferred in 120 lesions (111 patients) with FFR > or = 0.75. ACS was present in 35 patients (40 lesions). The clinical, angiographic and coronary hemodynamic characteristics of patients with and without ACS were similar. Among the 35 patients with ACS, there were 3 deaths, 1 MI, and 6 target vessel revascularizations (TVRs) (15% of lesions). Among the 76 patients without ACS, there were 5 deaths, 1 MI, and 7 TVR's (9% of lesions). Deferral of revascularization based on FFR in patients with ACS and moderate coronary stenoses is associated with acceptable and low event rates at 1 year.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 049831584

Download citation: RISBibTeXText

PMID: 16969847

DOI: 10.1002/ccd.20748


Related references

Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes. Jacc. Cardiovascular Interventions 11(23): 2434, 2018

Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes. Jacc. Cardiovascular Interventions 11(15): 1437-1449, 2018

Seven-year clinical outcomes of patients with moderate coronary artery stenosis after deferral of revascularization based on gray-zone fractional flow reserve. Cardiovascular Intervention and Therapeutics 30(3): 209-215, 2016

A comparison of the outcome of therapy between fractional flow reserve guided- versus coronary angiography guided-strategy in acute coronary syndrome patients with moderate coronary lesions. Zhonghua Nei Ke Za Zhi 55(7): 520-524, 2017

Comparison of medical treatment and coronary revascularization in patients with moderate coronary lesions and fractional flow reserve measurements between 0.75 and 0.80. 2007

Comparison of medical treatment and coronary revascularization in patients with moderate coronary lesions and borderline fractional flow reserve measurements. Catheterization and Cardiovascular Interventions 71(4): 541-548, 2008

Outcome of coronary lesions with deferred revascularization due to negative fractional flow reserve in subjects with acute coronary syndrome. International Journal of Cardiology 230: 335-338, 2017

Long-term outcome after deferral of revascularization in patients with intermediate coronary stenosis and gray-zone fractional flow reserve. Circulation Journal 79(1): 91-95, 2016

Clinical outcome in patients with intermediate or equivocal left main coronary artery disease after deferral of surgical revascularization on the basis of fractional flow reserve measurements. American Heart Journal 152(1): 156.E1-9, 2006

Impact of Routine Fractional Flow Reserve on Management Decision and 1-Year Clinical Outcome of Patients With Acute Coronary Syndromes: PRIME-FFR (Insights From the POST-IT [Portuguese Study on the Evaluation of FFR-Guided Treatment of Coronary Disease] and R3F [French FFR Registry] Integrated Multicenter Registries - Implementation of FFR [Fractional Flow Reserve] in Routine Practice). Circulation. Cardiovascular Interventions 10(6), 2018

One-year follow up after deferral of PTCA in intermediate coronary lesions showing discordant outcomes between fractional flow reserve and coronary blood flow velocity reserve. Circulation 104(17 Suppl.): II 456, October 23, 2001

Long-term outcome of discordance between fractional flow reserve and coronary flow velocity reserve after deferral of percutaneous coronary intervention using the clinically adopted 0.80 FFR cut-off. European Heart Journal 34(Suppl 1): P3979-P3979, 2013

Clinical outcome in patients with intermediate stenosis of left anterior descending coronary artery after deferral of revascularization on the basis of noninvasive coronary flow reserve measurement. Echocardiography 26(4): 431-440, 2008

The prognostic value of stenosis resistance index after deferral of percutaneous transluminal coronary angioplasty in intermediate coronary lesions showing discordant results between fractional and coronary blood flow velocity reserve. Journal of the American College of Cardiology 41(6 Suppl. A): 29A-30A, March 19, 2003

Long-term clinical outcomes after deferral of percutaneous coronary intervention of intermediate coronary stenoses based on coronary pressure-derived fractional flow reserve. Journal of Cardiology 58(1): 32-37, 2011