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Oxygen-dependent mechanisms underlying the antiischemic effect of verapamil and amlodipine



Oxygen-dependent mechanisms underlying the antiischemic effect of verapamil and amlodipine



Bulletin of Experimental Biology and Medicine 137(1): 40-42



Verapamil and amlodipine produced a potent antiischemic effect and reduced the area of myocardial infarction in rats. The observed changes were accompanied by inhibition of lipid peroxidation. In contrast to verapamil, amlodipine in a dose of 50 ng/ml in vitro decreased hemoglobin affinity for oxygen. Moreover, amlodipine in a concentration of 2 ng/ml decreased the content of malonic dialdehyde and activity of superoxide dismutase in the blood.

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Accession: 049839087

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PMID: 15085242

DOI: 10.1023/b:bebm.0000024382.81356.04


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