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P 53 and PCNA in Non Hodgkin's lymphoma--an immunohistochemical evaluation

P 53 and PCNA in Non Hodgkin's lymphoma--an immunohistochemical evaluation

Indian Journal of Pathology and Microbiology 43(1): 61-64

P 53 positivity and PCNA labelling index were studied in 50 cases of node based Non Hodgkin's lymphomas, P 53 positivity was observed in a spectrum of these disorders, suggesting that P 53 mutations play a role in the genesis of these tumours. P 53 positivity incresed from low through intermediate to high grade tumours and thus may be of prognostic value in these lesions. PCNA labelling index (LI) was higher in high grade tumours. P 53 and PCNA immunoreactivity showed a relationship in that PCNA LI was seen to be more than 30% in P 53 positive tumours. P 53 positivity appears to be related to the subtype and proliferation rate of NHL.

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Accession: 049839742

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PMID: 12583422

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