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Passive immunization against poliomyelitis: the Hammon gamma globulin field trials, 1951-1953



Passive immunization against poliomyelitis: the Hammon gamma globulin field trials, 1951-1953



American Journal of Public Health 95(5): 790-799



Poliomyelitis has gone from being one of the worst scourges of the 20th century to nearing eradication in the 21st. This success is well known to be attributable to the Salk inactivated and Sabin attenuated poliovirus vaccines.However, before introduction of these vaccines, William McDowall Hammon of the University of Pittsburgh Graduate School of Public Health led the first major breakthrough in prevention of the disease by using passive immunization in one of the earliest double-blind, placebo-controlled clinical trials. This study provided the first evidence that antibodies to poliovirus could prevent the disease in humans.

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Accession: 049862570

Download citation: RISBibTeXText

PMID: 15855454

DOI: 10.2105/ajph.2004.040790


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