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Phototoxic drugs and age-related maculopathy

Phototoxic drugs and age-related maculopathy

Journal Francais d'Ophtalmologie 26(6): 596-601

To disclose a correlation between age-related macular degeneration (AMD) and long-lasting treatments with potentially phototoxic drugs. Case-control study. The case group was made up of 90 randomized patients, 65 years old or older, with documented AMD, examined in 1998 and 1999. The M/F sex ratio was 0.54, and mean age 79.9 years. The control group was randomized with age- and sex-matched subjects. In both groups, we noted long-lasting oral treatment for hypertension, diabetes mellitus, epilepsy, hyperuricemia, and psychiatric pathologies. All the study group patients underwent a complete ophthalmological examination for visual acuity, contrast sensitivity, biomicroscopy, fundus color and red-free photographs, fluorescein and ICG angiographies. When the study group was compared with the control group, neovascular AMD was positively associated with thiazide diuretics (p<0.001). When the study group was analyzed alone, intake of one or several antihypertensive drugs was positively associated with occult neovascularization and mild to moderate visual loss (p=0.009). Only thiazide diuretic intake was positively associated with severe bilateral loss of vision (p=0.041) and extensive choroidal neovascularization with major subretinal hemorrhages (p=0.022). These findings suggest that severe neovascular AMD is associated with long-term thiazide diuretic treatment.

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Accession: 049918791

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PMID: 12910199

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