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Predicting intellectual outcome among children treated with 35-40 Gy craniospinal irradiation for medulloblastoma



Predicting intellectual outcome among children treated with 35-40 Gy craniospinal irradiation for medulloblastoma



Neuropsychology 17(4): 548-555



Fifty children diagnosed with medulloblastoma completed 188 psychological evaluations using the Wechsler Intelligence Scales for Children (D. Wechsler, 1974, 1991) over a 7-year study period following 35-40 Gy postoperative craniospinal irradiation. Random coefficient models were used to predict the trend in the children's intellectual performance as a function of time since diagnosis, with both patient and treatment variables as parameters of this function. A quadratic model demonstrated a delay prior to decline in performance for older patients, whereas the younger patients showed an immediate loss of performance with a plateau at approximately 6 years postdiagnosis. A steeper decline was found for those with higher baseline performance. Clinicians may use the proposed predictive model to identify those patients who are at risk of significant intellectual decline.

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Accession: 049974986

Download citation: RISBibTeXText

PMID: 14599268

DOI: 10.1037/0894-4105.17.4.548


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