+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Predictive value of parathyroid scintigraphy in the preoperative evaluation of patients with primary hyperparathyroidism



Predictive value of parathyroid scintigraphy in the preoperative evaluation of patients with primary hyperparathyroidism



Scandinavian Journal of Surgery 95(3): 199-204



The surgical gold standard in primary hyperparathyroidism was until recently exploration of all four parathyroid glands. Today more patients undergo minimal invasive procedures demanding more accurate preoperative localization studies. The aim of the study was to determine the positive predictive value (PPV) of parathyroid scintigraphy (PS) and to some extent ultrasonography (US), defined as the probability of finding one single adenoma on the affected side at surgery when the scans had shown one single focus. Eighty-eight surgically treated patients (76 women and 12 men, 8 with multiglandular disease) were included. The PS consisted of 99mTc-sestamibi scan with dual-phase technique, both planar and SPECT imaging, followed by 99mTc-pertechnetate scan. A positive scan was defined as a single focus accumulating sestamibi. Focal lesions on US were defined as hypoechoic nodules. PS was positive in 80 patients. Seventy-nine had only one focus, of which 64 were correctly localized adenomas (PPV 81%). Forty-seven of 77 US examinations were positive. In 44 there was only one focus of which 38 were correctly localized (PPV 86%). PPV was 97% when both examinations were positive. Both PS and US have acceptably high PPVs defined as the ability to predict whether or not one single focus represents a parathyroid adenoma. Concordant positive results were accompanied by a PPV close to 100%.

(PDF emailed within 0-6 h: $19.90)

Accession: 049977223

Download citation: RISBibTeXText

PMID: 17066618

DOI: 10.1177/145749690609500314


Related references

Preoperative predictive factors for parathyroid carcinoma in patients with primary hyperparathyroidism. Journal of Korean Medical Science 27(8): 890-895, 2012

The value of scintigraphy and ultrasonography in the preoperative localization of parathyroid glands in patients with primary hyperparathyroidism and concomitant thyroid disease. Hormones 5(1): 42-51, 2006

Preoperative parathyroid scintigraphy in primary hyperparathyroidism. Tidsskrift for den Norske Laegeforening 121(19): 2274-2277, 2001

The accuracy of 99m Tc-MIBI scintigraphy for preoperative parathyroid localization in primary and secondary-tertiary hyperparathyroidism. Journal of the Medical Association of Thailand 95 Suppl 3: S81-S91, 2012

Preoperative localization of parathyroid adenoma with sonography and 99mTc-sestamibi scintigraphy in primary hyperparathyroidism. Journal of Clinical Ultrasound 35(4): 186-190, 2007

Sensitivity of 3-Dimensional Sonography in Preoperative Evaluation of Parathyroid Glands in Patients With Primary Hyperparathyroidism. Journal of Ultrasound in Medicine 36(9): 1897-1904, 2017

Dual isotope subtraction parathyroid scintigraphy in the preoperative evaluation of suspected hyperparathyroidism. Clinical Nuclear Medicine 10(4): 300-314, 1985

Preoperative evaluation of hyperparathyroidism: the role of dual-phase parathyroid scintigraphy and ultrasound imaging. Annals of Nuclear Medicine 22(2): 123-131, 2008

Preoperative parathyroid localization: a prospective evaluation of ultrasonography and thallium-technetium scintigraphy in hyperparathyroidism. Canadian Journal of Surgery. Journal Canadien de Chirurgie 33(3): 175-180, 1990

Ultrasonography for preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism: comparison with (99m)technetium sestamibi scintigraphy. Clinical Endocrinology 57(2): 241-249, 2002

Preoperative localization of parathyroid adenomas using 99mTc-MIBI scintigraphy in patients with hyperparathyroidism. International Journal of Urology 4(2): 126-129, 1997

Parathyroid four-dimensional computed tomography: evaluation of radiation dose exposure during preoperative localization of parathyroid tumors in primary hyperparathyroidism. World Journal of Surgery 36(6): 1335-1339, 2012

Differential findings of tc-99m sestamibi dual-phase parathyroid scintigraphy between benign and malignant parathyroid lesions in patients with primary hyperparathyroidism. Nuclear Medicine and Molecular Imaging 45(4): 276-284, 2011

Preoperative ultrasound and thallium-technetium subtraction scintigraphy in localizing parathyroid lesions in patients with hyperparathyroidism. American Surgeon 59(8): 509-11; Discussion 511-2, 1993

The added value of parathyroid venous sampling for preoperative parathyroid adenoma localization by dynamic 4DCT in patients with recurrent primary hyperparathyroidism. Journal of Vascular and Interventional Radiology 25(3): S65-S66, 2014