+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prekallikrein (Fletcher Factor) Deficiency and Prolongation of APTT Reaction



Prekallikrein (Fletcher Factor) Deficiency and Prolongation of APTT Reaction



Medizinische Klinik 98(10): 587-590



Prekallikrein (Fletcher factor) is a protein of the contact phase of the blood coagulation system. A deficiency is a very rare event. The clinical meaning is still unknown. In a 24-year-old patient of Croatian nationality, who has never suffered from any kind of proneness to hemorrhage, a considerable prolongation of activated partial thromboplastin time (APTT) was diagnosed preoperatively. The prothrombin time (PT) was normal. The patient had to be subjected to horseshoe-kidney surgery. CLOTTING TESTS: A very seldom Fletcher factor (prekallikrein) deficiency type II was detected. The activity was < 1%, but the prekallikrein concentration was normal, comparable to that in normal plasma. Complications were neither noticed during renal surgery nor postoperatively. The patient did not show clinical symptoms. This fact corroborates reports about similar cases published earlier. Nevertheless, attention has to be paid to these exceptionally rare symptoms, as in some publications, thromboembolic or even bleeding complications were reported.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 049981482

Download citation: RISBibTeXText

PMID: 14586514

DOI: 10.1007/s00063-003-1299-0


Related references

Severe Fletcher factor (plasma prekallikrein) deficiency with partial deficiency of Hageman factor (factor XII): report of a case with observation on in vivo and in vitro leukocyte chemotaxis. American Journal of Hematology 12(3): 261-270, 1982

Prekallikrein (Fletcher factor) deficiency. Annals of Clinical and Laboratory Science 15(4): 279-285, 1985

Prekallikrein (Fletcher factor) deficiency in typhoid fever. Archives of Internal Medicine 141(12): 1701-1703, 1981

Prekallikrein (Fletcher factor) deficiency in clinical disease states. Thrombosis Research 18(1-2): 45-54, 1980

Applying a direct aPTT ratio (PlatelinLS/ActinFS) permits to identify rapidly and reliably a bleeding-related factor deficiency or a lupus anticoagulant sequential to an isolated prolongation of aPTT in paediatric pre-operative screening. European Journal of Haematology 96(6): 578-585, 2016

Clinical and physiologic studies of two siblings with prekallikrein (Fletcher factor) deficiency. American Journal of Medicine 60(5): 654-664, 1976

The Fletcher factor-prekallikrein deficiency: a diagnostic test which identifies heterozygotes. Thrombosis Research 5(3): 375-378, 1974

Multiple cerebral thrombosis in Fletcher factor (prekallikrein) deficiency: a case report. American Journal of Hematology 19(4): 387-393, 1985

Plasma prekallikrein (Fletcher factor) deficiency in a patient with chronic lymphocytic leukemia. Southern Medical Journal 73(12): 1653-1655, 1980

Prekallikrein deficiency: The characteristic normalization of the severely prolonged aPTT following increased preincubation time is due to autoactivation of factor XII. Thrombosis Research 105(6): 463-470, 2002

Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr). Thrombosis and Haemostasis 90(6): 1040-1045, 2003

Fletcher factor deficiency. A diminished rate of Hageman factor activation caused by absence of prekallikrein with abnormalities of coagulation, fibrinolysis, chemotactic activity, and kinin generation. Journal of Clinical Investigation 53(2): 622-633, 1974

Prevalent factor XII deficiency in cancer patients with isolated aPTT prolongation. Blood Research 50(2): 114-117, 2015

A patient with isolated prolongation of aPTT without hemorrhagic diathesis anamnesis: severe, hereditary factor XII deficiency. Therapeutische Umschau. Revue Therapeutique 56(9): 509-512, 1999

APTT Prolonged by Prekallikrein Deficiency. Laboratory Medicine 29(5): 274-276, 1998