+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Preparation and characterization of polyion complex micelles with a novel thermosensitive poly(2-isopropyl-2-oxazoline) shell via the complexation of oppositely charged block ionomers



Preparation and characterization of polyion complex micelles with a novel thermosensitive poly(2-isopropyl-2-oxazoline) shell via the complexation of oppositely charged block ionomers



Langmuir 23(1): 138-146



Novel thermosensitive polyion complex (PIC) micelles were prepared in an aqueous medium based on the complexation of a pair of oppositely charged block ionomers, poly(2-isopropyl-2-oxazoline)-b-poly(amino acid)s (PiPrOx-b-PAA), containing thermosensitive PiPrOx segments. The controlled synthesis of PiPrOx-b-PAA was achieved via the ring-opening anionic polymerization of N-carboxyanhydrides (NCA) of either eta-benzyloxycarbonyl-l-lysine (Lys(Z)-NCA) or beta-benzyl-l-aspartate (BLA-NCA) with omega-amino-functionalized PiPrOx macroinitiators and the subsequent deprotection reaction under acidic or basic conditions. Gel permeation chromatography (GPC) and 1H NMR spectroscopy revealed that the syntheses of two block ionomers, poly(2-isopropyl-2-oxazoline)-b-poly(l-lysine) [PiPrOx-P(Lys)] and poly(2-isopropyl-2-oxazoline)-b-poly(aspartic acid) [PiPrOx-P(Asp)], proceeded almost quantitatively to give samples with a narrow molecular weight distribution (Mw/Mn

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 049988463

Download citation: RISBibTeXText

PMID: 17190496

DOI: 10.1021/la061431j


Related references

Encapsulation of myoglobin in PEGylated polyion complex vesicles made from a pair of oppositely charged block ionomers: a physiologically available oxygen carrier. Angewandte Chemie 46(32): 6085-6088, 2007

Preparation of polyion complex micelles from poly(ethylene glycol)-block-polyions. Journal of Controlled Release 156(2): 118-127, 2011

Facile and Quantitative Synthesis of a Poly(ethylene glycol)-b-Poly(l-arginine) Block Copolymer and Its Use for the Preparation of Polyion Complex Micelles with Polyanions for Biomedical Applications. Macromolecular Rapid Communications 36(21): 1916-1922, 2015

Polyion complex micelles from plasmid DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: Physicochemical properties of micelles relevant to gene transfection efficiency. Biomaterials 24(24): 4495-4506, 2003

Preparation of a biodegradable matrix through polyion complex formation by mixing polylactide-based microspheres having oppositely charged surfaces. Journal of Colloid and Interface Science 270(2): 299-303, 2004

Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles relevant to gene transfection efficacy. Biomacromolecules 5(6): 2128-2136, 2004

Crystallisation-driven self-assembly of poly(2-isopropyl-2-oxazoline)-block-poly(2-methyl-2-oxazoline) above the LCST. Soft Matter 11(17): 3354-3359, 2015

Pronounced activity of enzymes through the incorporation into the core of polyion complex micelles made from charged block copolymers. Journal of Controlled Release 72(1-3): 85-91, 2001

Preparation of Polyion Complex Micelles Using Block Copolymers for SiRNA Delivery. Methods in Molecular Biology 1364: 89, 2016

Physicochemical properties and nuclease resistance of antisense-oligodeoxynucleotides entrapped in the core of polyion complex micelles composed of poly(ethylene glycol)-poly(L-lysine) block copolymers. European Journal of Pharmaceutical Sciences 13(1): 35-42, 2001

Complexation of Polyelectrolyte Micelles with Oppositely Charged Linear Chains. Journal of Physical Chemistry. B 121(8): 1982-1991, 2017

Stabilization of lysozyme-incorporated polyion complex micelles by the omega-end derivatization of poly(ethylene glycol)-poly(alpha,beta-aspartic acid) block copolymers with hydrophobic groups. Langmuir 21(7): 2668-2674, 2005

Synthesis and characterization of polyion complex micelles between poly(ethylene glycol)-grafted poly(aspartic acid) and cetyltrimethyl ammonium bromide. Colloids and Surfaces A: Physicochemical and Engineering Aspects 278(1-3): 60-66, 2006

Passive targeting of thermosensitive diblock copolymer micelles to the lungs: synthesis and characterization of poly(N-isopropylacrylamide)-block-poly(ε-caprolactone). Journal of Nanobiotechnology 13: 42, 2015

Polyplex Micelles with Double-Protective Compartments of Hydrophilic Shell and Thermoswitchable Palisade of Poly(oxazoline)-Based Block Copolymers for Promoted Gene Transfection. Biomacromolecules 17(1): 354-361, 2016