+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Primary malignant melanoma of the oral cavity: a case report



Primary malignant melanoma of the oral cavity: a case report



International Journal of Dermatology 43(10): 750-752



A 43-year-old white man was referred to the Special Care Dentistry Center of the School of Dentistry, University of Sao Paulo, Brazil, for the diagnosis of an extensive nodular lesion of the maxillary gingiva. The patient complained that his left maxilla had swollen over the last 4 months, with some exudation from the gingival crevice, sporadic bleeding, and slight tooth mobility, but no pain. An extra-oral examination confirmed expressive swelling of the left side of the face (Fig. 1A). Palpation disclosed bilateral enlargement of the submandibular lymph nodes. An intra-oral examination showed an extensive, reddish, nodular mass (around 11 cm in diameter) that extended from the last left maxillary molar to the right maxillary incisor, covered by a mucosa that was ulcerated in some areas (Fig. 1B,C). Palpation revealed a painless, soft, bleeding tissue that seemed to arise in the periodontal ligaments, extending to the palate and vestibular area. A small pigmented spot was found in the palatal mass. Histopathologically, the biopsy revealed a proliferation of neoplastic cells that exhibited a wide variety of shapes, including spindle, plasmacytoid, and epithelioid forms. The atypical cells showed enlarged and pleomorphic nuclei. Mitotic activity and pigmented areas were observed (Fig. 2A,B). Immunohistochemistry was used to establish the final diagnosis. The tumor cells strongly expressed S100 protein, gp100 (HMB-45), melan A, and tyrosine antibodies (Fig. 2C,D). With the diagnosis of malignant melanoma, the patient was referred to an oncologist for treatment. As computed tomography revealed that the lesion was deeply inserted into the skull surface (Fig. 1D), surgical intervention was not possible. The patient underwent radiotherapy, but died 14 months later.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 050013863

Download citation: RISBibTeXText

PMID: 15485534

DOI: 10.1111/j.1365-4632.2004.02334.x


Related references

Primary malignant melanoma of the oral cavity. Case report and establishment of melanoma cell line. International Journal of Oral Surgery 10(Suppl 1): 16-20, 1981

Primary malignant melanoma of the oral cavity: case report. International Journal of Dermatology 41(3): 178-181, 2002

Primary malignant melanoma of the oral cavity. A case report. Journal of Oral Medicine 38(4): 147-149, 1983

Primary malignant melanoma of the oral cavity: a case report. Journal of Oral and Maxillofacial Surgery 47(6): 621-622, 1989

Primary malignant melanoma of the oral cavity: report of case. Journal of Oral Surgery Anesthesia and Hospital Dental Service 18: 336-339, 1960

Primary malignant melanoma of the oral cavity. Report of a case. Oral Surgery Oral Medicine and Oral Pathology 28(4): 464-470, 1969

Primary Malignant Melanoma Of The Oral Cavity; Report Of A Case. Oral Surgery, Oral Medicine, and Oral Pathology 18: 77-79, 1964

Malignant melanoma as a primary lesion in the oral cavity. Case report. Revista Da Faculdade de Odontologia de Pernambuco 3(0): 97, 1971

Primary malignant melanoma of the oral cavity Report of an unusual case. Australian Dental Journal 43(5): 379-381, 1998

Primary malignant melanoma of the oral cavity. Report of an unusual case. Australian Dental Journal 43(6): 379-381, 1998

Primary malignant melanoma of the oral cavity. Report of an unusual case. Australian Dental Journal 43(4): 379-381, 1998

Primary malignant melanoma of the oral cavity: a case report and review. Schweizer Monatsschrift für Zahnmedizin 101(8): 997, 1991

Primary Malignant Melanoma of the Oral Cavity Treated by Surgery: Report of Case. Journal of Oral Surgery 23: 463-467, 1965

Primary malignant melanoma of the oral cavity. Report of a case. Review of the literature. Anales Otorrinolaringologicos Ibero-Americanos 28(1): 69-74, 2001

Primary malignant melanoma of the oral cavity: report of four cases. Kyoto Daigaku Kokukagaku Kiyo. Bulletin of Stomatology Kyoto University 7(1): 65-76, 1967