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Reactive barium-promoted Reformatsky-type reaction of alpha-chloroketones with aldehydes



Reactive barium-promoted Reformatsky-type reaction of alpha-chloroketones with aldehydes



Chemical Communications 2004(5): 580-581



A Reformatsky-type aldol reaction of alpha-chloroketones with aldehydes has been achieved using reactive barium as a low-valent metal in THF; this one-pot process is more effective for obtaining the desired beta-hydroxy ketones in high yields than the stepwise process in which barium enolates are prepared prior to the reaction with aldehydes.

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Accession: 050121397

Download citation: RISBibTeXText

PMID: 14973617

DOI: 10.1039/b314752p


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