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Recent advances in catalytic, enantioselective alpha aminations and alpha oxygenations of carbonyl compounds

Recent advances in catalytic, enantioselective alpha aminations and alpha oxygenations of carbonyl compounds

Angewandte Chemie 44(28): 4292-4300

The direct introduction of either a nitrogen or oxygen atom adjacent to a carbonyl group in a catalytic, enantioselective manner using both chiral Lewis acid and Lewis base catalysis has been described recently. The enantiomerically enriched products of these reactions, such as alpha-amino acids, represent fundamental building blocks for the construction of complex natural products and other important bioactive molecules. This Minireview provides a synopsis of this ever-growing field and highlights some of the challenges that still remain.

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Accession: 050125680

Download citation: RISBibTeXText

PMID: 15945110

DOI: 10.1002/anie.200462314

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