+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Regulation of components of the brain and cardiac renin-angiotensin systems by 17beta-estradiol after myocardial infarction in female rats

Regulation of components of the brain and cardiac renin-angiotensin systems by 17beta-estradiol after myocardial infarction in female rats

American Journal of Physiology. Regulatory Integrative and Comparative Physiology 291(1): R155-R162

ISSN/ISBN: 0363-6119

PMID: 16455770

DOI: 10.1152/ajpregu.00497.2005

The present study tested the hypothesis that 17beta-estradiol (E2) inhibits increases in angiotensin-converting enzyme (ACE) and ANG II type 1 receptor (AT1R) in the brain and heart after myocardial infarction (MI) and, thereby, inhibits development of left ventricular (LV) dysfunction after MI. Age-matched female Wistar rats were treated as follows: 1) no surgery (ovary intact), 2) ovariectomy + subcutaneous vehicle treatment (OVX + Veh), or 3) OVX + subcutaneous administration of a high dose of E2 (OVX + high-E2). After 2 wk, rats were randomly assigned to coronary artery ligation (MI) and sham operation groups and studied after 3 wk. E2 status did not affect LV function in sham rats. At 2-3 wk after MI, impairment of LV function was similar across MI groups, as measured by echocardiography and direct LV catheterization. LV ACE mRNA abundance and activity were increased severalfold in all MI groups compared with respective sham animals and to similar levels across MI groups. In most brain nuclei, ACE and AT1R densities increased after MI. Unexpectedly, compared with the respective sham groups the relative increase was clearest (20-40%) in OVX + high-E2 MI rats, somewhat less (10-15%) in ovary-intact MI rats, and least (< 10-15%) in OVX + Veh MI rats. However, because in the sham group brain ACE and AT1R densities increased in the OVX + Veh rats and decreased in the OVX + high-E2 rats compared with the ovary-intact rats, actual ACE and AT1R densities in most brain nuclei were modestly higher (< 20%) in OVX + Veh MI rats than in the other two MI groups. Thus E2 does not inhibit upregulation of ACE in the LV after MI and amplifies the percent increases in ACE and AT1R densities in brain nuclei after MI, despite E2-induced downregulation in sham rats. Consistent with these minor variations in the tissue renin-angiotensin system, during the initial post-MI phase, E2 appears not to enhance or hinder the development of LV dysfunction.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 050150536

Download citation: RISBibTeXText

Related references

Regulation of components of the brain and cardiac renin-angiotensin systems by 17b-estradiol after myocardial infarction in female rats. American Journal of Physiology 291(1): 55-R162, 2006

Inhibition of brain renin-angiotensin system improves diastolic cardiac function following myocardial infarction in rats. Clinical and Experimental Pharmacology and Physiology 36(8): 803-809, 2009

Biochemical remodeling of myocardial collagen and its relation to cardiac renin-angiotensin system in rats after myocardial infarction. Hua Xi Yi Ke da Xue Xue Bao 32(1): 9-11, 2001

Activation of protective and damaging components of the cardiac renin-angiotensin system after myocardial infarction in experimental diabetes. Journal of the Renin-Angiotensin-Aldosterone System: Jraas 8(2): 66-73, 2007

Changes in cardiac and circulating renin-angiotensin system after myocardial infarction in rats. Xi'an Yike Daxue Xuebao 15(4): 314-317, 1994

Brain renin-angiotensin system and sympathetic hyperactivity in rats after myocardial infarction. American Journal of Physiology. Heart and Circulatory Physiology 276(5): H1608-H1615, 2018

Brain renin-angiotensin system and sympathetic hyperactivity in rats after myocardial infarction. American Journal of Physiology 276(5): H1608-H1615, 1999

Renal vasoconstriction in rats with normal cardiac output following myocardial infarction role of the renin angiotensin system. Journal of the American Society of Nephrology 2(3): 523, 1991

Transforming growth factor-beta blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction. Endocrinology 149(11): 5828-5834, 2008

Os 32-02 Effects Of Renin-Angiotensin System Inhibitors On Vagina And Cardiac Expression Of Raas Components In Female Spontaneously Hypertensive Rats. Journal of Hypertension 34 Suppl 1 - Ish 2016 Abstract Book (): E390-E390, 2016

Brain renin-angiotensin system blockade with orally active aminopeptidase A inhibitor prevents cardiac dysfunction after myocardial infarction in mice. Journal of Molecular and Cellular Cardiology 127: 215-222, 2019

The brain Renin-Angiotensin system and the regulation of prolactin secretion in female rats: influence of ovarian hormones. Journal of Neuroendocrinology 1(4): 299-303, 1989

Rats with Low Brain Angiotensinogen Maintain Normal Levels of Insulin and Components of the Circulating and Intra-Renal Renin-Angiotensin Systems During Aging. FASEB Journal 18(4-5): Abst 474 11, 2004

Effect of renin-angiotensin system inhibitors on long-term survival in patients treated with beta blockers and antiplatelet agents after acute myocardial infarction (from the MONICA/KORA Myocardial Infarction Registry). American Journal of Cardiology 114(3): 329-335, 2014

Angiotensin II receptor blocker attenuates intrarenal renin-angiotensin-system and podocyte injury in rats with myocardial infarction. Plos one 8(6): E67242, 2013