+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Role of gravity in mammalian development: effects of hypergravity and/or microgravity on the development of skeletal muscles



Role of gravity in mammalian development: effects of hypergravity and/or microgravity on the development of skeletal muscles



Uchu Seibutsu Kagaku 18(3): 124-125



Effects of hindlimb suspension or exposure to 2-G between postnatal day 4 and month 3 and of 3-month recovery at 1-G environment on the characteristics of rat hindlimb muscles were studied. Pronounced growth inhibition was induced by unloading, but not by 2-G loading. It is suggested that the development and/or differentiation of soleus muscle fibers are closely associated with gravitational loading. The data indicated that gravitational unloading during postnatal development inhibits the myonuclear accretion in accordance with subnormal numbers of both mitotic active and quiescent satellite cells. Even though the fiber formation and longitudinal fiber growth were not influenced, cross-sectional growth of muscle fibers was also inhibited in association with lesser myonuclear domain and DNA content per unit volume of myonucleus. Unloading-related inhibition was generally normalized following the recovery.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 050233751

Download citation: RISBibTeXText

PMID: 15858352


Related references

Effects of Gravity, Microgravity or Microgravity Simulation on Early Mammalian Development. Stem Cells and Development 27(18): 1230-1236, 2018

Effects of microgravity and hypergravity on early development stages of Xeonopus laevis. Journal of Gravitational Physiology 9(1): P207-P208, 2002

Effects of gravity, hypergravity and microgravity on vestibular neurones of the crab. Journal of Gravitational Physiology 11(2): P1-P4, 2004

The role of gravity in the evolutionary emergence of multicellular complexity: microgravity effects on arthropod development and aging. Advances in Space Research 23(12): 2075-2082, 1999

Functional plasticity of mammalian skeletal muscles under microgravity. Aviakosmicheskaia i Ekologicheskaia Meditsina 40(1): 27-35, 2006

Responses across the gravity continuum: hypergravity to microgravity. Advances in Space Biology and Medicine 10: 225-245, 2005

Walking in neonatal rats exposed to microgravity or hypergravity during postnatal development. Society for Neuroscience Abstracts 23(1-2): 637, 1997

Simulated Microgravity and Hypergravity Attenuate Heart Tissue Development in Explant Culture. Cells Tissues Organs 167(2-3): 171-183, 2000

Simulated microgravity and hypergravity attenuate heart tissue development in explant culture. Cells, Tissues, Organs 167(2-3): 171-183, 2000

Hypergravity resistance exercise: the use of artificial gravity as potential countermeasure to microgravity. Journal of Applied Physiology 103(5): 1879-1887, 2007

EMG activity of three rat hindlimb muscles during microgravity and hypergravity phase of parabolic flight. Aviation, Space, and Environmental Medicine 69(11): 1065-1070, 1998

Effects of simulated microgravity on mammalian fertilization and preimplantation embryonic development in vitro. Fertility & Sterility 74(6): 1142-1147, 2000

Effects of microgravity on myogenic factor expressions during postnatal development of rat skeletal muscle. Journal of Applied Physiology 92(5): 1936-1942, 2002

Electron microscopic observations of satellite cells with special reference to the development of mammalian skeletal muscles. Zeitschrift für Anatomie und Entwicklungsgeschichte 125(1): 43-63, 1966

Long-Term Effects of Simulated Microgravity and Vibration Exposure on Skeletal Development in Zebrafish. Stem Cells and Development 27(18): 1278-1286, 2018