+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Role of tissue factor in thrombosis. Coagulation-inflammation-thrombosis circuit

Role of tissue factor in thrombosis. Coagulation-inflammation-thrombosis circuit

Frontiers in Bioscience 11: 256-271

Tissue factor (TF) plays a role in thrombogenesis. TF initiates blood coagulation resulting in the generation of protease coagulant mediators (FVIIa, FXa, and FIIa) and fibrin production. TF hypercoagulablility directly contributes to thrombus formation resulting from the major events of fibrin deposition and FIIa-induced platelet activation/aggregation. In addition, blood coagulation indirectly promotes thrombogenicity via the coagulation-inflammation cycle in which TF plays a diverging and converging role. As the consequence of coagulation-dependent inflammation in which protease-activated receptor (PAR) mediates the coagulant signaling to elicit cytokines, selectins, and growth factors, such inflammation facilitates thrombosis by platelet aggregation and leukocyte recruitment. As TF hypercoagulability concerned, anti-thrombotic strategies involve the prevention by anticoagulation and PAR antagonism. Anticoagulants block the direct and indirect thrombotic contributions, while PAR antagonists arrest coagulation-dependent inflammation. With respect to both thrombosis and inflammation being cardiovascular risk factors, such strategies offer diverse benefits to cardioprotection.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 050238397

Download citation: RISBibTeXText

PMID: 16146730

Related references

Role of tissue factor in thrombosis. Coagulation-inflammation- thrombosis circuit. Frontiers in Bioscience 11: 256-271, 2006

Tissue factor upregulation drives a thrombosis-inflammation circuit in relation to cardiovascular complications. Cell Biochemistry and Function 24(2): 173-192, 2004

Role of tissue factor in haemostasis, thrombosis, angiogenesis and inflammation: lessons from low tissue factor mice. Thrombosis and Haemostasis 92(3): 444-450, 2004

Tissue factor: newer concepts in thrombosis and its role beyond thrombosis and hemostasis. Cardiovascular Diagnosis and Therapy 8(5): 581-593, 2018

Coagulation factor XII in thrombosis and inflammation. Blood 131(17): 1903-1909, 2018

Coagulation factor VII. (Biochemistry, role in blood coagulation, methods of assay, congenital deficiencies and relationship with thrombosis). La Ricerca in Clinica e in Laboratorio 13(3): 287-298, 1983

Interleukin 8 and venous thrombosis Evidence for a role of inflammation in the development of thrombosis. Blood 94(10 Suppl. 1 Part 1): 24a, 1999

Interleukin 8 and venous thrombosis: Evidence for a role of inflammation in thrombosis. British Journal of Haematology 116(1): 173-177, 2002

Administration of a small molecule tissue factor/factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time. Thrombosis Research 112(3): 167-174, 2003

The missing link between atherosclerosis, inflammation and thrombosis: is it tissue factor?. Expert Review of Cardiovascular Therapy 9(4): 517-523, 2011

Evaluation of a novel small protein inhibitor of the blood coagulation factor VIIa/tissue factor complex in animal models of arterial and venous thrombosis. Circulation 94(8 Suppl. ): I695, 1996

In vivo evidence for a role of coagulation factor XI as an anti-fibrinolytic factor in an rabbit jugular vein thrombosis model. Fibrinolysis & Proteolysis 12(Suppl. 1): 18, 1998

Thrombosis. Thrombosis : Advances on diagnosis and treatment. Disease state and diagnosis of thrombotic diseases. Multiple small vein thrombosis. Diseminated intravascular coagulation syndrome (DIC). Nihon Naika Gakkai Zasshi 86(6): 915-922, 1997

Tissue factor in the heart. Multiple roles in hemostasis, thrombosis, and inflammation. Trends in Cardiovascular Medicine 11(8): 307-312, 2001

Tissue factor, the emerging link between inflammation, thrombosis, and vascular remodeling. Circulation Research 89(1): 1-2, 2001