+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

SARS, possible zoonosis in the area of conflict of pathogenic coronaviruses of animals

SARS, possible zoonosis in the area of conflict of pathogenic coronaviruses of animals

Schweizer Archiv für Tierheilkunde 145(7): 316-322

Severe acute respiratory syndrome (SARS) is an emerging disease, which was first recognized in Guangdong Province, China, in November 2002. In the meantime, SARS has been recognized in patients on all five continents. A novel coronavirus, which is not related to the hitherto known coronaviruses, has been proven to be associated with the disease. Our genomic analyses strongly suggest that the new SARS-coronavirus did not emerge through mutation or recombination and that it has probably been transmitted from a so far not identified animal species to humans. Therefore, it is most likely that SARS virus is a zoonotic agent. A broad body of knowledge originating from research in veterinary medicine indicates that development of vaccines against the SARS-coronavirus may be problematic. The potential danger of such vaccines should not be neglected during the process of vaccine development.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 050245775

Download citation: RISBibTeXText

PMID: 12894604

Related references

SARS-agent and lessons to be learned from pathogenic coronaviruses of animals. SAT, Schweizer Archiv fur Tierheilkunde 145(7): 316-322, 2003

Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans. Journal of General Virology 91(Pt 4): 1058-1062, 2010

SARS and other coronaviruses in humans and animals. Advances in Experimental Medicine and Biology 581: 457-462, 2006

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses. Antiviral Research 100(1): 286-295, 2014

Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses. Science China. Life Sciences 60(12): 1399-1402, 2017

The SARS-like coronaviruses: the role of bats and evolutionary relationships with SARS coronavirus. New Microbiologica 35(1): 1-16, 2012

Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. Plos Pathogens 13(11): E1006698, 2017

Phylogenetic perspectives on the epidemiology and origins of SARS and SARS-like coronaviruses. Infection Genetics and Evolution 9(6): 1185-1196, 2009

Emergence of pathogenic coronaviruses in cats by homologous recombination between feline and canine coronaviruses. Plos one 9(9): E106534, 2014

Antigenic cross-reactivity between the nucleocapsid protein of severe acute respiratory syndrome (SARS) coronavirus and polyclonal antisera of antigenic group I animal coronaviruses: implication for SARS diagnosis. Journal of Clinical Microbiology 42(5): 2351-2352, 2004

Pathogenic murine coronaviruses. II. Characterization of virus-specific proteins of murine coronaviruses JHMV and A59V. Virology 94(2): 371-384, 1979

SARS and other "New" Coronaviruses. Coronaviruses: Molecular and Cellular Biology): 287-297, 2007

SARS- and other coronaviruses. Methods in Molecular Biology 454: V-Vi, 2008

SARS/avian coronaviruses. Developments in Biologicals 126: 161-9; Discussion 326-7, 2006

Coronaviruses. Causes of SARS and other infections. Medizinische Monatsschrift für Pharmazeuten 27(1): 4, 2004