+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Seeing the light: protein theories of general anesthesia. 1984

Seeing the light: protein theories of general anesthesia. 1984

Anesthesiology 101(1): 235-237

Most proteins are insensitive to the presence of general anaesthetics at concentrations which induce anaesthesia, while some are inhibited by some agents but not others. Here we show that, over a 100000-fold range of potencies, the activity of a pure soluble protein (firefly luciferase) can be inhibited by 50% at anaesthetic concentrations which are essentially identical to those which anaesthetize animals. This identity holds for inhalational agents (such as halothane, methoxyflurane and chloroform), aliphatic and aromatic alcohols, ketones, ethers and alkanes. This finding is all the more striking in view of the fact that the inhibition is shown to be competitive in nature, with anaesthetic molecules competing with the substrate (luciferin) molecules for binding to the protein. We show that the anaesthetic-binding site can accommodate only one large, but more than one small, anaesthetic molecule. The obvious mechanism suggested by our results is that general anaesthetics, despite their chemical and structural diversity, act by competing with endogenous ligands for binding to specific receptors.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 050269621

Download citation: RISBibTeXText

PMID: 15220795

Related references

Theories of general anesthesia. Journal of Pharmacology and Experimental Therapeutics 98(4:2): 121-160, 1950

History and theories of general anesthesia. Goodman, Louis S And Alfred Gilman (Edited By) The Pharmacological Basis Of Therapeutics 4th Edition Xx + 1794p Illus The Macmillan Co : New York, N Y , U S A ; London, England 42-48, 1970

New theories in molecular mechanisms of general anesthesia. Masui. Japanese Journal of Anesthesiology 57(1): 4-21, 2008

Theories of anesthesia general perturbations vs specific receptors. 1980

Thoracic peridural anesthesia combined with light general anesthesia: hemodynamic data and echocardiography. Annales Francaises D'anesthesie et de Reanimation 8 Suppl: R102-R102, 1989

Circulatory response to endolaryngeal microsurgery under light general anesthesia and the influence of surface anesthesia. Anesthesia and Analgesia 48(6): 953-957, 1969

Network Activity Changes during General Anesthesia Provide Support for Neurobiological Theories of Conscious Awareness. Anesthesiology Abstracts of Scientific Papers Annual Meeting ( ): Abstract No A-796, 2002

Comparison of the cardiorespiratory effects of sevoflurane and isoflurane during epidural anesthesia combined with light general anesthesia under spontaneous ventilation. Nihon University Journal of Medicine 40(2): 71-79, April, 1998

Thoracic epidural anesthesia associated with light general anesthesia in high risk surgical patients effects on left ventricular function. Anesthesiology (Hagerstown) 69(3A): A181, 1988

Adrenergic receptors viewed in light of general receptor theories. Annals of the New York Academy of Sciences 139(3): 632-644, 1967

Epidural light general versus conventional general anesthesia for resection of abdominal aortic aneurysm aaa. Journal of Cardiovascular Surgery 30(5 SUPPL): 101, 1989

Some Aspects Of The Problem Of Cure And Experimental Therapy In The Light Of General Theories On Diseases. Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 8: 84-86, 1964

A comparison of epidural anesthesia, general anesthesia, and general anesthesia + ropivicaine 3 in 1 block for arthroscopic anterior cruciate ligament repair. Regional Anesthesia & Pain Medicine 23(3 SUPPL ): 120, May-June, 1998

Comments on the paper by G. Grosse. Caudal anesthesia combined with general anesthesia in comparison with general anesthesia in outpatient circumcision. Der Anaesthesist 38(12): 700-701, 1989