+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Semipermeable polymer vesicle (PICsome) self-assembled in aqueous medium from a pair of oppositely charged block copolymers: physiologically stable micro-/nanocontainers of water-soluble macromolecules



Semipermeable polymer vesicle (PICsome) self-assembled in aqueous medium from a pair of oppositely charged block copolymers: physiologically stable micro-/nanocontainers of water-soluble macromolecules



Journal of the American Chemical Society 128(18): 5988-5989



A new entity of polymer vesicle with a polyion complex (PIC) membrane, a PICsome, was prepared by simple mixing of a pair of oppositely charged block copolymers, composed of biocompatible PEG and poly(amino acid)s, in an aqueous medium. Flow particle image analysis revealed the formation of spherical particles with a size range up to 10 mum. Observation by dark-field and confocal laser scanning microscopes clearly confirmed that the PICsome has a hollow structure with an inner-water phase, in which FITC-dextran emitting green fluorescence was successfully encapsulated simply by the simultaneous mixing with the block copolymers. Confocal laser scanning microscopic observation and spectral analysis revealed the smooth penetration of a low molecular weight fluorescent dye (TRITC; MW = 443.5) emitting red fluorescence into the FITC-dextran encapsulated PICsome to give the PICsome image with a merged color of yellows, indicating the semipermeable nature of the PICsome membrane. The PICsomes showed appreciable physiological stability even in the presence of serum proteins, suggesting their feasibility in biomedical fields such as carriers of therapeutic compounds and compartments for diagnostic enzymes.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 050278118

Download citation: RISBibTeXText

PMID: 16669639

DOI: 10.1021/ja057993r


Related references

Induction of Secondary Structure through Micellization of an Oppositely Charged Pair of Homochiral Block- and Homopolypeptides in an Aqueous Medium. Macromolecular Rapid Communications 36(22): 1958-1964, 2015

Encapsulation of myoglobin in PEGylated polyion complex vesicles made from a pair of oppositely charged block ionomers: a physiologically available oxygen carrier. Angewandte Chemie 46(32): 6085-6088, 2007

Charge-conversional PEG-polypeptide polyionic complex nanoparticles from simple blending of a pair of oppositely charged block copolymers as an intelligent vehicle for efficient antitumor drug delivery. Molecular Pharmaceutics 11(5): 1562-1574, 2014

Mixtures of cationic copolymers and oppositely charged surfactants: effect of polymer charge density and ionic strength on the adsorption behavior at the silica-aqueous interface. Acs Applied Materials and Interfaces 4(3): 1500-1511, 2012

Micelles from PEO-PPO-PEO block copolymers as nanocontainers for solubilization of a poorly water soluble drug hydrochlorothiazide. Colloids and Surfaces. B Biointerfaces 83(1): 49-57, 2011

The electrostatic co-assembly in non-stoichiometric aqueous mixtures of copolymers composed of one neutral water-soluble and one polyelectrolyte (either positively or negatively charged) block: a dissipative particle dynamics study. Physical Chemistry Chemical Physics 18(24): 16137-16151, 2016

Assemblies of double hydrophilic block copolymers and oppositely charged dendrimers. Langmuir 25(3): 1345-1351, 2009

Electrostatic self-assembly of neutral and polyelectrolyte block copolymers and oppositely charged surfactant. Journal of Physical Chemistry. B 111(40): 11700-7, 2007

Stoichiometric polyelectrolyte complexes of ionic block copolymers and oppositely charged polyions. Journal of Chemical Physics 125(19): 194902, 2006

Molecular bottle brushes in a solution of semiflexible polyelectrolytes and block copolymers with an oppositely charged block: a molecular dynamics simulation. Journal of Physical Chemistry. B 111(29): 8360-8368, 2007

Salt effect on complex formation of neutral/polyelectrolyte block copolymers and oppositely charged surfactants. Langmuir 24(11): 5707-5713, 2008

Chain length recognition: core-shell supramolecular assembly from oppositely charged block copolymers. Science 283(5398): 7, 1999

Aggregation of water-soluble block copolymers in aqueous solutions: recent trends. Advances in Colloid and Interface Science 123-126: 75-96, 2006

Complexes of polyelectrolyte-neutral double hydrophilic block copolymers with oppositely charged surfactant and polyelectrolyte. Journal of Physical Chemistry. B 111(29): 8351-8359, 2007

Rheological Properties of Silica Suspensions in Aqueous Solutions of Block Copolymers and Their Water-Soluble Components. Journal of Colloid and Interface Science 241(1): 293-295, 2001