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Sickle cell crisis and endothelin antagonists

Sickle cell crisis and endothelin antagonists

Critical Care Nursing Quarterly 26(3): 225-229

Sickle cell crisis may be more complex than a vaso-occlusive event in response to hypoxia. Endothelin-1 (ET-1) is a potent vasoconstrictor and mitogen secreted in response to hypoxia. ET-1 contributes to the vaso-occlusion and inflammation in sickle cell crisis. ET-1 antagonists may be useful in the prevention and treatment of crisis.

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Accession: 050304379

Download citation: RISBibTeXText

PMID: 12930038

DOI: 10.1097/00002727-200307000-00008

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