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Sterol regulatory element-binding protein (SREBP) -1: gene regulatory target for insulin resistance?

Kotzka, J.; Müller-Wieland, D.

Expert Opinion on Therapeutic Targets 8(2): 141-149

2004


ISSN/ISBN: 1744-7631
PMID: 15102555
DOI: 10.1517/14728222.8.2.141
Accession: 050386775

The combined appearance of different cardiovascular risk factors seems to be more prevalent in individuals with decreased insulin sensitivity and increased visceral obesity, thereby being components of the so-called metabolic syndrome. Alterations in transcription factors result in complex dysregulation of gene expression, which might be the key to understanding insulin resistance-associated clinical clustering of coronary risk factors at the cellular or gene regulatory level. Recent examples are peroxisome proliferator-activated receptors and sterol regulatory element-binding proteins (SREBPs), which also appear to be novel drug targets. The authors have recently shown that SREBPs are substrates of mitogen-activated protein kinases, and propose that SREBP-1 might play a role in the development of cellular features belonging to lipotoxicity and, possibly, syndrome X.

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