Synthesis, X-ray crystal structure, anti-fungal and anti-cancer activity of [Ag2 (NH3) 2 (salH) 2] (salH2=salicylic acid)
Coyle, B.; McCann, M.; Kavanagh, K.; Devereux, M.; McKee, V.; Kayal, N.; Egan, D.; Deegan, C.; Finn, G.J.
Journal of Inorganic Biochemistry 98(8): 1361-1366
ISSN/ISBN: 0162-0134 PMID: 15271512 DOI: 10.1016/j.jinorgbio.2004.04.016
[Ag(2)(NH(3))(2)(salH)(2)] (salH(2)=salicylic acid) was synthesised from salicylic acid and Ag(2)O in concentrated aqueous NH(3) and the dimeric Ag(I) complex was characterised using X-ray crystallography. The complex is centrosymmetric with each metal coordinated to a salicylate carboxylate oxygen and to an ammonia nitrogen atom in an almost linear fashion. The two [Ag(NH(3))(salH)] units in the complex are linked by an Ag-Ag bond. Whilst metal-free salH(2) did not prevent the growth of the fungal pathogen Candida albicans [Ag(2)(NH(3))(2)(salH)(2)], [Ag(2)(salH)(2)] and some simple Ag(I) salts greatly inhibited cell reproduction. SalH(2), [Ag(2)(NH(3))(2)(salH)(2)] [Ag(2)(salH)(2)] and AgClO(4) produced a dose-dependent cytotoxic response against the three human derived cancer cell lines, Cal-27, Hep-G2 and A-498, with the Ag(I)-containing reagents being the most effective.