The chemical structure of normal human brain and Tay-Sachs gangliosides
Svennerholm, L.
Biochemical and Biophysical Research Communications 9: 436-441
1962
ISSN/ISBN: 0006-291X PMID: 13979552 DOI: 10.1016/0006-291x(62)90030-x
Accession: 050584661
Normal human brains contain mono- and disialogangliosides. The latter can be converted to the major monosialoganglioside by enzymic hydrolysis with neuraminidase. Partial acid degradation of the monosialoganglioside has given four neutral ceramide - saccharides which have been isolated and characterised. The ganglioside accumulated into the brain in Tay-Sachs disease has been shown to lack the galactose in end position.