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The discovery of an enantioselective receptor for (-)-adenosine from a racemic dynamic combinatorial library



The discovery of an enantioselective receptor for (-)-adenosine from a racemic dynamic combinatorial library



Journal of the American Chemical Society 128(38): 12422-3



The use of laser polarimetry detection coupled with HPLC is demonstrated to enable the discovery of enantioselective receptors from racemic dynamic combinatorial libraries. Templating with an enantiopure analyte, such as (-)-adenosine, leads to amplification of one enantiomer of the cyclic dimer. A result confirmed with a pseudo-racemic library wherein one of the enantiomers was d-labeled for mass spec analysis. The resulting dimer is thus an enantioselective receptor for (-)-adenosine.

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Accession: 050604308

Download citation: RISBibTeXText

PMID: 16984185

DOI: 10.1021/ja0647699


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