+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The prevalence and clinical characteristics of hepatitis-delta infection in Korea



The prevalence and clinical characteristics of hepatitis-delta infection in Korea



Korean Journal of Hepatology 11(1): 43-50



The prevalence of hepatitis delta virus (HDV) infection has been estimated as being approximately 5% among global HBsAg carriers. The anti-delta positive rate in Koreans had been reported as being 0.85% in 1985. While the prevalence of HBV has been decreased from nearly 10% to 5% during the past twenty years, there have been no more studies on the anti-delta prevalence in Koreans. The aim of this study was to estimate the anti-delta prevalence in Koreans and to study the clinical characteristics of anti-delta positive patients in a single center. Serum anti-delta was measured in one hundred ninety four HBsAg-positive patients who were admitted to our hospital from February 2003 to August 2003. We checked the genotypes of the HBV in the anti-delta positive patients. The clinical features of the anti-delta positive patients were compared to those clinical features of the anti-delta negative patients from the aspect of age, gender, mode of transmission, the positivity of HBeAg and serum HBV DNA. Serum anti-delta was positive in seven patients among the 194 subjects, giving a 3.6% positive rate. Among these seven patients, six had hepatocellular carcinoma (HCC) and the other one had cholangiocarcinoma. All of the anti-delta positive patients had the C genotype of HBV. The anti-delta positive patients showed significantly suppressed HBV DNA replication compared to the anti-delta negative patients. In Koreans, anti-delta was positive mainly in HCC patients with an approximate prevalence of 4%, and this rate has not changed much for the past twenty years. HBV DNA replication was suppressed by HDV infection.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 050698245

Download citation: RISBibTeXText

PMID: 15788884


Related references

Prevalence and clinical significance of hepatitis D virus co-infection in patients with chronic hepatitis B in Korea. Journal of Medical Virology 83(7): 1172-1177, 2011

Prevalence of hepatitis delta virus (HDV) infection in chronic hepatitis B patients with unusual clinical pictures. Hepatitis Monthly 13(8): E6731, 2013

Prevalence and associated clinical characteristics of hepatitis B, C, and HIV infections among injecting drug users in Korea. Journal of Medical Virology 85(4): 575-582, 2013

Delta infection in asymptomatic carriers of hepatitis B surface antigen: low prevalence of delta activity and effective suppression of hepatitis B virus replication. Hepatology 8(5): 1121-1124, 1988

Prevalence and clinical significance of occult hepatitis B virus infection among renal transplant recipients in Korea. Scandinavian Journal of Infectious Diseases 44(10): 788-792, 2012

Prevalence And Clinical Course Of Hepatitis Delta Infection In Gree A 13-Year Prospective Study. 2013

Prevalence and clinical course of hepatitis delta infection in Greece: a 13-year prospective study. Journal of Hepatology 59(5): 949-956, 2013

Hepatitis B virus infection in Chinese patients with hepatitis C virus infection: prevalence, clinical characteristics, viral interactions and host genotypes: a nationwide cross-sectional study. Bmj Open 6(10): E012016, 2016

Occult hepatitis B: prevalence and clinical characteristics in a population with high endemicity of hepatitis B infection in the western Brazilian Amazon region. Revista Da Sociedade Brasileira de Medicina Tropical 41(6): 596-601, 2009

Prevalence and clinical features of hepatitis delta virus infection in the Miyako Islands, Okinawa, Japan. Journal of Gastroenterology 33(6): 850-854, 1998

Hepatitis delta virus infection and Labrea hepatitis. Prevalence and role in fulminant hepatitis in the Amazon Basin. JAMA 258(4): 479-483, 1987

The prevalence of hepatitis delta virus infection in acute and chronic liver diseases in Turkey: an analysis of clinical studies. Turkish Journal of Gastroenterology 17(1): 25-34, 2006

Search for hepatitis delta virus (HDV) infection in hepatitis C patients in northeastern Poland. Comparison with anti-HDV prevalence in chronic hepatitis B. European Journal of Epidemiology 18(6): 559-561, 2003