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Toward transition metal-catalyzed carbonylation of methanol without HI as copromoter: catalytic exocyclic carbonylation of cycloimino esters


Organic Letters 5(21): 3955-3957
Toward transition metal-catalyzed carbonylation of methanol without HI as copromoter: catalytic exocyclic carbonylation of cycloimino esters
[reaction: see text] Initial studies of a rare exocyclic C-O bond carbonylation are reported. Under the catalysis of Co(2)(CO)(8) in the absence of HI as the copromoter, cycloimino esters are carbonylated to afford N-acyllactams in high yields under relatively mild conditions (100-160 degrees C and 200-1000 psi). The reaction is interesting because it opens up the possibility of carbonylation of alcohols in the absence of HI.

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Accession: 050808280

PMID: 14535752

DOI: 10.1021/ol035616i



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