+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality



Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality



International Journal of Cancer 118(12): 3099-3111



This study profiles testicular cancer incidence and mortality across Europe, and the effects of age, period and generational influences, using age-period-cohort modeling. Despite a 5-fold variation in incidence rates, there were consistent mean increases in incidence in each of the 12 European countries studied, ranging from around 6% per annum (Spain and Slovenia) to 1-2% (Norway). In contrast, declines in testicular cancer mortality of 3-6% per annum were observed in the 1980s and 1990s for the majority of the 22 countries studied, particularly in Northern and Western Europe. The mortality trends in several European countries were rather stable (Romania and Bulgaria) or increasing (Portugal and Croatia). Short-term attenuations in increasing cohort-specific risk of incidence were indicated among men born between 1940 and 1945 in 7 European countries. In Switzerland, successive generations born from the mid 1960s may have experienced a steadily declining risk of disease occurrence. While the underlying risk factors responsible remain elusive, the temporal and geographical variability in incidence may point to an epidemic in different phases in different countries-the result of country-specific differences in the prevalence of one or several ubiquitous and highly prevalent environmental determinants of the disease. Advances in treatment have led to major declines in mortality in many European countries from the mid 1970s, which has translated to cohorts of men at successively lower risk of death from the disease. Slower progress in the delivery of optimal care is however evident from the mortality trends in several lower-resource countries in Southern and Eastern Europe. The first beneficiaries of therapy in these populations may be those men born--rather than diagnosed--in the era of major breakthrough in testicular cancer care.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 050852838

Download citation: RISBibTeXText

PMID: 16395710

DOI: 10.1002/ijc.21747


Related references

Time trends in testicular cancer in Croatia 1983-2007: rapid increases in incidence, no declines in mortality. Cancer Epidemiology 36(1): 11-15, 2012

Breast cancer incidence and mortality trends in 16 European countries. European Journal of Cancer 39(12): 1718-1729, 2003

Prostate cancer incidence and mortality trends in 37 European countries: an overview. European Journal of Cancer 46(17): 3040-3052, 2010

Thriving for clues in variations seen in mortality and incidence of cancer: geographic patterns, temporal trends, and human population diversities in cancer incidence and mortality. Methods in Molecular Biology 471: 137-159, 2009

A comparison of trends in incidence and mortality rates of breast cancer, incidence to mortality ratio and stage at diagnosis between Arab and Jewish women in Israel, 1979-2002. European Journal of Cancer Prevention 16(1): 36-42, 2007

Global trends in testicular cancer incidence and mortality. European Urology 60(2): 374-379, 2011

Testicular cancer incidence in eight northern European countries: secular and recent trends. Cancer Epidemiology, Biomarkers & Prevention 13(12): 2157-2166, 2004

National cancer incidence is estimated using the incidence/mortality ratio in countries with local incidence data: is this estimation correct?. Cancer Epidemiology 37(3): 270-277, 2013

Recent global trends in testicular cancer incidence and mortality. Medicine 97(37): E12390, 2018

International variations and trends in testicular cancer incidence and mortality. European Urology 65(6): 1095-1106, 2015

Testicular cancer in the United States: trends in incidence and mortality. International Journal of Epidemiology 15(2): 164-170, 1986

Prostate and breast cancer in four Nordic countries: A comparison of incidence and mortality trends across countries and age groups 1975-2013. International Journal of Cancer 141(11): 2228-2242, 2017

Diverging trends in incidence and mortality of testicular cancer in Denmark, 1943-1982. British Journal of Cancer 53(4): 501-505, 1986

Temporal trends in age-specific incidence and mortality of breast cancer in 38 countries. 2007

Interpreting trends in prostate cancer incidence and mortality in the five Nordic countries. Journal of the National Cancer Institute 99(24): 1881-1887, 2007