+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

"Fighting an uphill battle": experience with the HCV triple therapy: a qualitative thematic analysis



"Fighting an uphill battle": experience with the HCV triple therapy: a qualitative thematic analysis



Bmc Infectious Diseases 14: 507



Hepatitis C virus (HCV) infections are a severe burden on public health worldwide, causing mortality rates triple that of the general population. Since 2011, for both therapy-naive and therapy-experienced genotype 1 patients, the first generation of direct acting antivirals (DAAs), i.e., the protease-inhibitors (PI) telaprevir and boceprevir have been added to existing dual therapies. The therapeutic effect of the resulting triple therapy is striking; however, treatment regimens are complex and commonly cause side effects. Little is known of how patients implement therapy in their daily lives, or of how they deal with these effects.This study aims to describe HCV patients' experiences with protease-inhibitor-based triple therapy and their support needs. A qualitative design was used. Patients from three outpatient clinics, with ongoing, completed or discontinued PI treatment experience were recruited using a maximum variation sampling approach. Open-ended interviews were conducted and analyzed using thematic analysis according to Braun & Clarke (Qual Res Psychol 3:77-101, 2006). Thirteen patients participated in the interviews. All described themselves as highly motivated to undergo treatment, since they saw the new therapy as a "real chance" for a cure. However, all later described the therapy period as a struggle. The constitutive theme-"Fighting an uphill battle"- describes the common existential experience of and negative consequences of coping with side effects. The processes that fostered this common experience followed three sub-themes: "encountering surprises", "dealing with disruption" and "reaching the limits of systems". HCV patients undergoing outpatient protease-inhibitor-based triple therapy need systematic support in symptom management. This will require specially trained professionals to advise and support them and their families, and to provide rapid responses to their needs throughout this complex course of therapy. As the generation of DAAs for all genotypes, are expected to have less severe side effects, and many HCV patients require treatment, this knowledge can improve treatment support tremendously, especially for patients who are quite difficult to treat. Furthermore, these findings are helpful to illustrate development in HCV treatment.

(PDF emailed within 0-6 h: $19.90)

Accession: 051003129

Download citation: RISBibTeXText

PMID: 25231646

DOI: 10.1186/1471-2334-14-507


Related references

Fighting an uphill battle. 1996

Still fighting an uphill battle. Nursing Standard 1987) 26(9): 20-21, 2011

Geopressured energy fighting uphill battle. Science 207(4438): 1455-1456, 1980

Fighting earmarking in the federal budget is an uphill battle. BioScience 49(2): 4, 1999

Fighting an uphill battle: the recovery of frogs in Australia's Wet Tropics. Ecology 98(12): 3221-3223, 2017

Washington Watch: Fighting earmarking in the federal budget is an uphill battle. Bioscience 49(2): 104-104, 1999

Fighting an uphill battle: population pressure and declining land productivity in Rwanda. MSU International Development Working Papers ( 58): iv + 28 pp., 1996

Caring for the Critically Ill Alcoholic Liver Disease Patient: An Uphill Battle Worth Fighting. Critical Care Medicine 47(1): 123-124, 2018

Employees suffering from bipolar disorder or clinical depression: fighting an uphill battle for protection under Title I of the Americans with Disabilities Act. Seton Hall Law Review 29(4): 1347-1404, 1999

Feeling the pain, seeking to regain. Provider groups fighting uphill battle to repeal parts of the Balanced Budget Act of 1997. Modern Healthcare 29(14): 38, 56, 1999

Science Beyond the Pale: Researchers with maverick ideas--particularly in space physics--find themselves fighting an uphill battle for acceptance; should the system be more tolerant of unorthodoxy?. Science 249(4964): 14-16, 1990

Midwives' experiences with mother-infant skin-to-skin contact after a caesarean section: 'fighting an uphill battle'. Midwifery 31(1): 215-220, 2016

How suicide-bereaved family members experience the inquest process: a qualitative study using thematic analysis. International Journal of Qualitative Studies on Health and Well-Being 14(1): 1563430-1563430, 2019

Marriage and Family Therapy Trainees Experiences of Learning and Applying Common Factors in Therapy: A Qualitative Participatory Study With Thematic Analysis. Journal of Family PsychoTherapy 27(4): 276-287, 2016

Risky business or safety net? Trainee perceptions of personal therapy: a qualitative thematic analysis. European Journal of PsychoTherapy & Counselling 11(4): 369-384, 2009