+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Association of inflammatory mediators with pain perception

Association of inflammatory mediators with pain perception

Biomedicine and PharmacoTherapy 96: 1445-1452

Treatment of pain has always been a major goal in the clinic, as it is related to several pathological conditions of inflammatory origin and surgical procedures, which are associated with inflammatory mediators. Understanding the molecular mechanisms underlying the association between inflammatory mediators and pain perception, from peripheral to central sensitization, can provide the basis for the development of new pharmacological treatments. Despite safety concerns, till date, the use of non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to be efficacious, safe, and well tolerated by patients. Thus, choosing the appropriate administration route, developing new formulations and lowering the efficacious dose represent, currently, effective means of treating inflammation and relieving the pain, without inducing significant side effects.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 051029757

Download citation: RISBibTeXText

PMID: 29217162

DOI: 10.1016/j.biopha.2017.12.001

Related references

Altered pain perception in self-injurious behavior and the association of psychological elements with pain perception measures: a systematic review. Psychiatria Danubina 27(4): 346-354, 2015

Visceral perception: Inflammatory and non-inflammatory mediators. Gut 51(Suppl. 1): i19-i23, 2002

Attenuation of inflammatory pain by puerarin in animal model of inflammation through inhibition of pro-inflammatory mediators. International Immunopharmacology 61: 306-316, 2018

Cancer pain The contribution of mediators underlying inflammatory pain. Chapman, C R , Foley, K M Bristol-Myers Squibb Symposium on Pain Research Series; Current and emerging issues in cancer pain: Research and practice : 21-29, 1993

The ethyl acetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice. Journal of Ethnopharmacology 181: 26-36, 2016

Activation of the nociceptin opioid system in rat sensory neurons produces antinociceptive effects in inflammatory pain: involvement of inflammatory mediators. Journal of Neuroscience Research 85(7): 1478-1488, 2007

Cognitive mediators of pain perception and tolerance. Journal of Personality and Social Psychology 61(3): 504-510, 1991

Association of systemic and intra-articular osteoclastogenic potential, pro-inflammatory mediators and disease activity with the form of inflammatory arthritis. International Orthopaedics 38(1): 183-192, 2014

Investigating the spill-over hypothesis: analysis of the association between local inflammatory markers in sputum and systemic inflammatory mediators in plasma. Environmental Research 134: 24-32, 2014

Silencing of FKBP51 alleviates the mechanical pain threshold, inhibits DRG inflammatory factors and pain mediators through the NF-kappaB signaling pathway. Gene 627: 169-175, 2017

Trait mindfulness and catastrophizing as mediators of the association between pain severity and pain-related impairment. Personality and Individual Differences 66: 68-73, 2014

Inflammatory mediators of pain. British Journal of Anaesthesia 75(2): 125-131, 1995

Pain and inflammatory mediators. Vane, J R And S H Ferreira (Ed ) Handbook Of Experimental Pharmacology, Vol 50 No 1 Inflammation Xxvii+784p Springer-Verlag: New York, N Y , Usa: Berlin, West Germany Illus P588-616, 1978

The association between patients' perception of their overall quality of care and their perception of pain management in the prehospital setting. Prehospital Emergency Care 17(3): 386-391, 2014

Pain induced by inflammatory mediators. Beers, Rr. And E. G. Bassett (ed.). Miles International Symposium Series, No. 11. Mechanisms Of Pain And Analgesic Compounds, Baltimore, Md., Usa. Iii 496p. Raven Press: New York, N.y., Usa. Illus. P273-284, 1979