+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A 6-year-old girl with vaginal spotting who was diagnosed with perivascular epithelioid cell neoplasm after vaginoscopic resection

A 6-year-old girl with vaginal spotting who was diagnosed with perivascular epithelioid cell neoplasm after vaginoscopic resection

Obstetrics and Gynecology Science 57(5): 409-411

Perivascular epithelioid cell neoplasm (PEComa) is a rare tumor with unknown malignant potential. We report a case of a 6-year-old child with history of brain tumor (pineoblastoma), who presented with intermittent vaginal spotting for 6 months. A vaginoscopy revealed a 1.5×1.0-cm mass on the vaginal wall. Pathological examination demonstrated that the tumor was composed of clear cells with organoid patterns, which were immunohistochemically positive for HMB-45 and TFE3, and negative for CK, HNF1-B, SOX10, Melan A, and S-100 protein. These findings were consistent with PEComa arising from the vagina. Regular follow-up with magnetic resonance imaging has shown no signs of recurrence. This case shows that early detection of PEComa and subsequent regular follow-ups are important because of the neoplasm's unknown malignant potential.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 051057677

Download citation: RISBibTeXText

PMID: 25264534

DOI: 10.5468/ogs.2014.57.5.409

Related references

A heavily pigmented vaginal perivascular epithelioid cell neoplasm. Journal of Obstetrics and Gynaecology 29(7): 676-677, 2009

Comparative genomic hybridization study of perivascular epithelioid cell tumor: molecular genetic evidence of perivascular epithelioid cell tumor as a distinctive neoplasm. Human Pathology 37(5): 606-612, 2006

Perivascular epithelioid cell tumour of the vagina in an 8 year old girl. Journal of Pediatric Surgery 42(3): 564-566, 2007

Malignant mesenteric perivascular epithelioid cell neoplasm presenting as an intra-abdominal fistula in a 49-year-old female. Case Reports in Oncological Medicine 2014: 534175, 2014

Microscopic uterine lymphangioleiomyomatosis perivascular epithelioid cell neoplasm: a case report with the earliest manifestation of this enigmatic neoplasm. International Journal of Gynecological Pathology 30(1): 71-75, 2011

Perivascular epithelioid cell neoplasm of the colon. World Journal of Gastrointestinal Oncology 2(4): 205-208, 2010

Bladder perivascular epithelioid cell tumor: a novel rare neoplasm. Urologia Internationalis 88(4): 480-482, 2012

Microscopic endometrial perivascular epithelioid cell nodules: a case report with the earliest presentation of a uterine perivascular epithelioid cell tumor. Diagnostic Pathology 7: 117, 2012

Sinonasal perivascular epithelioid cell tumor: benign or malignant neoplasm?. American Journal of Rhinology and Allergy 26(3): 213-217, 2012

Cutaneous perivascular epithelioid cell tumors: A review on an infrequent neoplasm. World Journal of Methodology 6(1): 87-92, 2016

Primary retroperitoneal perivascular epithelioid cell neoplasm: A case report. Oncology Letters 10(1): 469-472, 2015

Perivascular epithelioid cell neoplasm (PEComa) of the uterus: A systematic review. International Journal of Surgery 19: 1-5, 2015

Malignant Perivascular Epithelioid Cell Neoplasm (PEComa) of the Pelvis: A Case Report. Urology Case Reports 6: 36-38, 2016

TFE3-Expressing Perivascular Epithelioid Cell Neoplasm (PEComa) of the Sella Turcica. Endocrine Pathology 28(1): 22-26, 2017

Perivascular epithelioid cell neoplasm (PEComa) originating from the pancreas and metastasizing to the liver. Pancreas 40(7): 1155-1157, 2011