+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays



A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays



Journal of Neuroscience Methods 188(2): 187-194



Many neurophysiological experiments on rodents and non-human primates involve the implantation of more than one multi-electrode array to record from many regions of the brain. So called 'floating' microelectrode arrays are implanted in cortical regions of interest and are coupled via a flexible cable to their connectors which are fixed to the skull by a cement cap or a titanium pedestal, such as the Cereport system, which has been approved for human use. The use of bone cement has several disadvantages including the creation of infection prone areas at the interface with the skull and surrounding skin. Alternatively, the more biocompatible Cereport has a limited carrying capacity and is far more expensive. In this paper, we describe a new implantation technique, which combines the biocompatibility of titanium, a high carrying capacity with a minimal skull footprint, and a decreased chance of infection, all in a relatively inexpensive package. This technique utilizes an in-house fabricated 'Nesting Platform' (NP), mounted on a titanium headpost to hold multiple connectors above the skin, making the headpost the only transcutaneous object. The use of delrin, a durable, lightweight and easily machinable material, allows easy customization of the NP for a wide variety of floating electrodes and their connectors. The ultimate result is a longer survival time with superior neural recordings that can potentially last longer than with traditional implantation techniques.

(PDF emailed within 0-6 h: $19.90)

Accession: 051080110

Download citation: RISBibTeXText

PMID: 20153370

DOI: 10.1016/j.jneumeth.2010.02.006


Related references

Histological studies of the effects of chronic implantation of ceramic-based microelectrode arrays and microdialysis probes in rat prefrontal cortex. Brain Research 1291: 12-20, 2009

A multiple floating microelectrode for chronic implantation and longterm single unit recording in the cat. Electroencephalography and Clinical Neurophysiology 58(3): 285-288, 1984

Successful long-term implantation of electrically inactive epiretinal microelectrode arrays in rabbits. Retina 19(6): 546-552, 1999

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model. Journal of Visualized Experiments 129), 2017

Multisite microelectrode arrays for measurements of multiple neurochemicals. Conference Proceedings 7: 5348-5351, 2007

A technique to prevent dural adhesions to chronically implanted microelectrode arrays. Journal of Neuroscience Methods 97(2): 93-101, April 15, 2000

Performance of amperometric sensors based on multiple microelectrode arrays. Sensors and Actuators B: Chemical 44(1-3): 538-541, 1997

Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes. Vision Research 51(17): 1897-1906, 2011

Micropatterning of poly(dimethylsiloxane) using a photoresist lift-off technique for selective electrical insulation of microelectrode arrays. Journal of Micromechanics and Microengineering 19: 65016-65016, 2009

Abiotic-biotic characterization of Pt/Ir microelectrode arrays in chronic implants. Frontiers in Neuroengineering 7: 2-2, 2014

PDMS-based conformable microelectrode arrays with selectable novel 3-D microelectrode geometries for surface stimulation and recording. Conference Proceedings 2009: 1623-1626, 2010

A technique for the chronic implantation of multiple movable micro-electrodes. Electroencephalography and Clinical Neurophysiology 27(2): 205-208, 1969

Chronic, percutaneous connector for electrical recording and stimulation with microelectrode arrays. Conference Proceedings 2014: 5240-5243, 2016

Chronic intracortical neural recordings using microelectrode arrays coated with PEDOT-TFB. Acta Biomaterialia 32(): 57-67, 2016

Chronic in vivo stability assessment of carbon fiber microelectrode arrays. Journal of Neural Engineering 13(6): 066002-066002, 2016