A case of postoperative multiple liver metastases of pancreatic cancer successfully treated by combination chemotherapy with weekly high-dose 5-FU hepatic arterial infusion plus systemic infusion of gemcitabine
Doh, J.; Sho, M.; Tanaka, T.; Yamada, T.; Nomi, T.; Akahori, T.; Yamato, I.; Nishiofuku, H.; Tamamoto, T.; Hasegawa, M.; Kichikawa, K.; Nakajima, Y.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 36(12): 2087-2089
ISSN/ISBN: 0385-0684 PMID: 20037332 Accession: 051092932
We report a case of a 65-year-old man with postoperative multiple liver metastases of pancreatic cancer successfully treated with weekly high-dose 5-FU hepatic arterial infusion chemotherapy plus systemic infusion of gemcitabine. The patient was admitted because of suffering from epigastralgia and jaundice. He underwent pancreaticoduodenectomy for pancreatic head cancer and received postoperative adjuvant chemotherapy of gemcitabine. Abdominal CT after 6 months showed multiple liver metastases. Then we started a systemic gemcitabine (1,000 mg/body) infusion and weekly high- dose 5-FU (1,500 mg/body) hepatic arterial infusion chemotherapy. After 26 times of treatment, CT indicated that the tumors completely disappeared. He survived for 34 months after surgery. It has been suggested that this combined chemotherapy might be an effective treatment to control liver metastases of pancreatic cancer.