Home
  >  
Section 52
  >  
Chapter 51,093

A case of postoperative multiple liver metastases of pancreatic cancer successfully treated by combination chemotherapy with weekly high-dose 5-FU hepatic arterial infusion plus systemic infusion of gemcitabine

Doh, J.; Sho, M.; Tanaka, T.; Yamada, T.; Nomi, T.; Akahori, T.; Yamato, I.; Nishiofuku, H.; Tamamoto, T.; Hasegawa, M.; Kichikawa, K.; Nakajima, Y.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 36(12): 2087-2089

2009

ISSN/ISBN: 0385-0684
PMID: 20037332
Accession: 051092932
Download citation:  
Text
  |  
BibTeX
  |  
RIS
We report a case of a 65-year-old man with postoperative multiple liver metastases of pancreatic cancer successfully treated with weekly high-dose 5-FU hepatic arterial infusion chemotherapy plus systemic infusion of gemcitabine. The patient was admitted because of suffering from epigastralgia and jaundice. He underwent pancreaticoduodenectomy for pancreatic head cancer and received postoperative adjuvant chemotherapy of gemcitabine. Abdominal CT after 6 months showed multiple liver metastases. Then we started a systemic gemcitabine (1,000 mg/body) infusion and weekly high- dose 5-FU (1,500 mg/body) hepatic arterial infusion chemotherapy. After 26 times of treatment, CT indicated that the tumors completely disappeared. He survived for 34 months after surgery. It has been suggested that this combined chemotherapy might be an effective treatment to control liver metastases of pancreatic cancer.

PDF emailed within 1 workday: $29.90




Related References

Oh, Y.-J.; Park, Y.-M.; Kim, B.-H.; Kim, M.-J.; Cho, J.-H.; Cha, C.-W.; Park, S.-J.; Yeon, J.-W. 2009: A case of hepatocellular carcinoma with pulmonary metastases treated successfully with a combination of repeated hepatic arterial infusion epirubicin and Cisplatin chemotherapy and systemic low-dose infusion of 5-Fluorouracil Gut and Liver 3(4): 343-348
Matsuoka, K.; Hisamatsu, T.; Aoyagi, S.; Motohashi, Y.; Ikezawa, T.; Tatsuno, S.; Mizuno, Y.; Nishida, J. 2001: A case of gastric cancer with liver metastases successfully treated with combination therapy of systemic and hepatic arterial infusion chemotherapy Gan to Kagaku Ryoho. Cancer and ChemoTherapy 28(2): 243-246
Kanoh, T.; Ohnishi, T.; Tono, T.; Takemoto, H.; Shiozaki, K.; Kimura, Y.; Iwazawa, T.; Nakano, Y.; Yano, H.; Monden, T. 2006: A case of successfully treated unresectable multiple liver metastases from colon cancer by hepatic arterial infusion chemotherapy and systemic chemotherapy Gan to Kagaku Ryoho. Cancer and ChemoTherapy 33(12): 1953-1955
Hashimoto, K.; Nio, Y.; Koike, M.; Itakura, M.; Yano, S.; Higami, T. 2004: A case of liver metastases of breast cancer successfully treated by combination chemotherapy using hepatic arterial infusion of docetaxel and systemic administration of trastuzumab Gan to Kagaku Ryoho. Cancer and ChemoTherapy 31(9): 1391-1393
Nakamura, Y.; Fujiwara, H.; Sonoyama, T.; Ochiai, T.; Shimizu, T.; Ichikawa, D.; Okamoto, K.; Sakakura, C.; Ueda, Y.; Itoi, H.; Otsuji, E.; Hagiwara, A.; Yamagishi, H.; Mitsuishi, Y.; Kishida, T. 2004: A case of unresectable multiple liver metastases from colon cancer successfully treated by hepatic arterial infusion chemotherapy and systemic immunotherapy (IFNANK) followed by hepatic resection Gan to Kagaku Ryoho. Cancer and ChemoTherapy 31(11): 1812-1814
Tajima, H.; Kitagawa, H.; Shoji, M.; Okamoto, K.; Nakanuma, S.; Sakai, S.; Kinoshita, J.; Makino, I.; Hayashi, H.; Nakamura, K.; Oyama, K.; Nakagawara, H.; Miyashita, T.; Takamura, H.; Ohta, T.; Minami, T.; Koda, W.; Sanada, J.; Gabata, T.; Sai, Y. 2013: Hepatic arterial infusion chemotherapy with gemcitabine for patients with postoperative liver metastases from pancreatic cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 40(12): 1668-1671
Mochizuki, R.; Gunji, Y.; Takayama, W.; Miyazaki, S.; Makino, H.; Matsushita, K.; Miyauchi, H.; Chiba, S.; Ochiai, T. 2004: A case of the 5-year survivor of ascending colon cancer associated with synchronous multiple liver metastasis and peritoneal dissemination successfully treated with combination therapy of systemic and hepatic arterial infusion chemotherapy Gan to Kagaku Ryoho. Cancer and ChemoTherapy 31(11): 1662-1664
Nakajima, N.; Hata, Y.; Matsuoka, S.; Itoh, T.; Maeda, Y.; Osada, T.; Sano, F. 2002: A case of gastric cancer associated with synchronous liver metastasis successfully treated with combination therapy of systemic and hepatic arterial infusion chemotherapy Gan to Kagaku Ryoho. Cancer and ChemoTherapy 29(12): 2442-2446
Ide, Y.; Okada, K.; Ohta, H.; Maruyama, K.; Yokouchi, H.; Kinuta, M.; Yasumoto, T.; Murata, K. 2007: A case of multiple liver metastases from rectal cancer in poor performance status successfully treated with hepatic arterial infusion chemotherapy plus CPT-11 Gan to Kagaku Ryoho. Cancer and ChemoTherapy 34(12): 2059-2061
Kusama, M.; Kaise, H.; Nakayama, S.; Oota, D.; Shimizu, H.; Aoki, T.; Koyanagi, Y. 2000: A case of breast cancer with multiple metastases successfully treated by medroxyprogesterone acetate with intermittent intra-arterial infusion low-dose chemotherapy to hepatic metastasis Gan to Kagaku Ryoho. Cancer and ChemoTherapy 27(14): 2243-2247
Fujimoto, T.; Yoshimatsu, K.; Yokomizo, H.; Umehara, A.; Watanabe, K.; Otani, T.; Matsumoto, A.; Osawa, G.; Itagaki, H.; Ogawa, K. 2007: Extra- and intra-hepatic metastasis successfully treated with alternative chemotherapy with hepatic arterial infusion and systemic intravenous infusion after responding to hepatic metastasis from colon cancer by hepatic arterial infusion--a case report Gan to Kagaku Ryoho. Cancer and ChemoTherapy 34(12): 1976-1978
Yamauchi, S.; Uetake, H.; Miyazaki, K.; Kikuchi, A.; Ono, H.; Kato, S.; Ishiguro, M.; Ishikawa, T.; Kobayashi, H.; Iida, S.; Higuchi, T.; Enomoto, M.; Sugihara, K. 2010: A case of colon cancer with multiple liver metastases effectively treated with hepatic arterial infusion followed by systemic chemotherapy Gan to Kagaku Ryoho. Cancer and ChemoTherapy 37(12): 2514-2516
Tajima, H.; Ohta, T.; Kitagawa, H.; Sakai, S.; Makino, I.; Hayashi, H.; Oyama, K.; Nakagawara, H.; Fujita, H.; Onishi, I.; Takamura, H.; Ninomiya, I.; Fushida, S.; Tani, T.; Fujimura, T.; Koda, W.; Minami, T.; Ryu, Y.; Sanada, J.; Gabata, T.; Matsui, O. 2011: Pilot study of hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for patients with postoperative liver metastases from pancreatic cancer Experimental and Therapeutic Medicine 2(2): 265-269
Suzuki, Y.; Yamaguchi, T.; Matsumoto, H.; Nakano, D.; Iwanaga, T.; Ohashi, M.; Iwasaki, Y.; Takahashi, K. 2009: A case report of multiple liver metastases from colorectal cancer effectively treated with systemic chemotherapy and hepatic arterial infusion Gan to Kagaku Ryoho. Cancer and ChemoTherapy 36(12): 2178-2180
Tajima, H.; Kitagawa, H.; Tsukada, T.; Okamoto, K.; Nakanuma, S.-I.; Sakai, S.; Makino, I.; Furukawa, H.; Hayashi, H.; Oyama, K.; Inokuchi, M.; Nakagawara, H.; Miyashita, T.; Itoh, H.; Fujita, H.; Takamura, H.; Ninomiya, I.; Fushida, S.; Fujimura, T.; Ohta, T.; Koda, W.; Minami, T.; Ryu, Y.; Sanada, J.; Gabata, T.; Matsui, O.; Sai, Y. 2013: Hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil or oral S-1 improves the prognosis of patients with postoperative liver metastases from pancreatic cancer Molecular and Clinical Oncology 1(5): 869-874
Iwauchi, T.; Amano, R.; Ohira, G.; Nakamoto, K.; Doi, Y.; Yamada, N.; Ohira, M.; Hirakawa, K. 2010: A case of liver metastasis of pancreatic cancer that was resistant to S-1 and gemcitabine successfully treated by 5-FU and cisplatin hepatic arterial infusion Gan to Kagaku Ryoho. Cancer and ChemoTherapy 37(12): 2373-2375
Roehrig, S.; Wein, A.; Albrecht, H.; Reulbach, U.; Maennlein, G.; Hohenberger, W.; Hahn, E.G.; Boxberger, F. 2016: Palliative systemic combination chemotherapy with gemcitabine (GEM) and weekly 24h-infusion of high-dose 5-fluorouracil (5- FU) in patients with metastatic pancreatic cancer (UICC stage IV) Journal of Clinical Oncology 26(15_Suppl): 15644-15644
Kanno, H.; Kitamura, M.; Suzuki, Y.; Imai, K.; Watanabe, K. 2005: A case of postoperative liver metastases from gastric cancer successfully treated with hepatic arterial infusion of paclitaxel Gan to Kagaku Ryoho. Cancer and ChemoTherapy 32(1): 89-91
Nagano, H.; Sakon, M.; Yasuda, T.; Dono, K.; Nakamori, S.; Yano, M.; Umeshita, K.; Shiozaki, H.; Okada, A.; Murakami, T.; Nakamura, H.; Monden, M. 2001: A case of postoperative multiple hepatic metastasis from esophageal cancer successfully treated by surgical resection and hepatic arterial infusion chemotherapy Gan to Kagaku Ryoho. Cancer and ChemoTherapy 28(11): 1628-1631
Watanabe, M.; Tsuchiya, M.; Takita, W.; Otsuka, Y.; Tamura, A.; Yamazaki, K.; Koshino, H.; Kurihara, A.; Kaneko, H.; Teramoto, T. 2006: Case report of a liver metastasis from rectal cancer achieving complete response (CR) by a combination of intra-hepatic arterial infusion of irinotecan (CPT-11) with degradable starch microspheres (DSM) and weekly high-dose intra-hepatic arterial chemotherapy with 5-FU Gan to Kagaku Ryoho. Cancer and ChemoTherapy 33(10): 1485-1488