+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

A case report of recurrent vascular access thrombosis in a hemodialysis patient reveals combined acquired and inherited thrombophilia



A case report of recurrent vascular access thrombosis in a hemodialysis patient reveals combined acquired and inherited thrombophilia



Therapeutic Apheresis and Dialysis 12(2): 190-192



Vascular access thrombosis represents a serious and unfortunately common problem in hemodialysis patients. Usually, but not always, this complication can be attributed to low access blood flow. However, there are some patients who experience thrombosis despite a well functioning vascular access. We describe the case of a 31-year-old Caucasian male, who was hemodialyzed via an arteriovenous fistula for two years due to Alport's syndrome. During this time period he had two episodes of vascular access thrombosis that destroyed two arteriovenous fistulas. Both fistulas were functioning well and the thrombosis events took place in days between the hemodialysis sessions. Thrombophilia was suspected and the relative investigation revealed high levels of factor VIII procoagulant, which is frequent in hemodialysis patients, and resistance to activated protein C. Polymerase chain reaction detected that the patient was heterozygous for factor V Leiden, which is quite common in general population. Thereafter, a new arteriovenous fistula was formed and the patient started oral anticoagulation therapy with warfarin. Now, three years after the last arteriovenous fistula formation, the patient is hemodialyzed without vascular access problems. In conclusion, evaluation of the coagulation cascade in hemodialysis patients with recurrent vascular access thrombosis is necessary.

(PDF emailed within 0-6 h: $19.90)

Accession: 051096747

Download citation: RISBibTeXText

PMID: 18387172

DOI: 10.1111/j.1744-9987.2008.00569.x


Related references

Inherited protein S deficiency due to a novel nonsense mutation in the PROS1 gene in the patient with recurrent vascular access thrombosis: A case report. Kidney Research and Clinical Practice 31(1): 72-75, 2012

Combined aspirin and sulfinpyrazone in the prevention of recurrent hemodialysis vascular access thrombosis. Thrombosis Research 62(6): 737-744, 1991

Thrombophilia and the risk for hemodialysis vascular access thrombosis. Journal of the American Society of Nephrology 16(4): 1108-1114, 2005

Role of thrombophilia in vascular access thrombosis among chronic hemodialysis patients in Tunisia. Therapeutic Apheresis and Dialysis 15(1): 40-43, 2011

Role of Increased Factor VIII Levels in Recurrent Thrombosis of Vascular Access: A Case Report. Saudi Journal of Kidney Diseases and Transplantation 17(1): 64-65, 2007

Thrombophilia--inherited and acquired susceptibility to thrombosis. Lijecnicki Vjesnik 131(7-8): 236-237, 2009

A Case of Recurrent First Trimester Miscarriages Due to Inherited Multifactorial Thrombophilia in an Otherwise Asymptomatic Patient: A Clinical Dilemma. Journal of Obstetrics and Gynaecology of India 68(5): 414-416, 2018

Axillary artery to right atrium shunt for hemodialysis access in a patient with advanced central vein thrombosis: a case report. Annals of Vascular Surgery 20(3): 418-421, 2006

Recurrent vascular access thrombosis in hemodialysis patients lack of demonstrable blood hypercoagulability. Haemostasis 16(SUPPL 5): 55, 1986

Recurrent intracardiac thrombosis as an unusual manifestation of inherited thrombophilia. International Journal of Cardiology 114(3): 380-381, 2006

Prevention of recurrent vascular access thrombosis in hemodialysis patients a pilot study using aspirin plus sulfinpyrazone. Haemostasis 16(SUPPL 5): 66, 1986

Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. Human Reproduction 21(10): 2694-2698, 2006

Contribution of recurrent venous thrombosis and inherited thrombophilia to the pathogenesis of postthrombotic syndrome. Clinical and Applied Thrombosis/Hemostasis 21(1): 87-90, 2015

Frequency of anti-heparin-platelet factor 4 antibodies in hemodialysis patients and correlation with recurrent vascular access thrombosis. American Journal of Hematology 69(1): 72-73, January, 2002

Recurrent vascular access thrombosis in hemodialysis patients is associated with homozygosity for the 677CfwdarwT mutation in the methylene tetrahydrofolate reductase gene. Journal of the American Society of Nephrology 9(PROGRAM AND ABSTR ISSUE): 157A, Sept, 1997