+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

A dynamic code of dorsal neural tube genes regulates the segregation between neurogenic and melanogenic neural crest cells

A dynamic code of dorsal neural tube genes regulates the segregation between neurogenic and melanogenic neural crest cells

Development 140(11): 2269-2279

ISSN/ISBN: 0950-1991

PMID: 23615280

DOI: 10.1242/dev.093294

Understanding when and how multipotent progenitors segregate into diverse fates is a key question during embryonic development. The neural crest (NC) is an exemplary model system with which to investigate the dynamics of progenitor cell specification, as it generates a multitude of derivatives. Based on 'in ovo' lineage analysis, we previously suggested an early fate restriction of premigratory trunk NC to generate neural versus melanogenic fates, yet the timing of fate segregation and the underlying mechanisms remained unknown. Analysis of progenitors expressing a Foxd3 reporter reveals that prospective melanoblasts downregulate Foxd3 and have already segregated from neural lineages before emigration. When this downregulation is prevented, late-emigrating avian precursors fail to upregulate the melanogenic markers Mitf and MC/1 and the guidance receptor Ednrb2, generating instead glial cells that express P0 and Fabp. In this context, Foxd3 lies downstream of Snail2 and Sox9, constituting a minimal network upstream of Mitf and Ednrb2 to link melanogenic specification with migration. Consistent with the gain-of-function data in avians, loss of Foxd3 function in mouse NC results in ectopic melanogenesis in the dorsal tube and sensory ganglia. Altogether, Foxd3 is part of a dynamically expressed gene network that is necessary and sufficient to regulate fate decisions in premigratory NC. Their timely downregulation in the dorsal neural tube is thus necessary for the switch between neural and melanocytic phases of NC development.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 051130484

Download citation: RISBibTeXText

Related references

The delayed entry of thoracic neural crest cells into the dorsolateral path is a consequence of the late emigration of melanogenic neural crest cells from the neural tube. Developmental Biology 200(2): 234-246, 1998

Avian neural crest cells express a melanogenic trait during early migration from the neural tube: observations with the new monoclonal antibody, MEBL-1. Development (Cambridge, England) 114: 7-78, 1992

From Neural Crest to Definitive Roof Plate: the Dynamic Behavior of the Dorsal Neural Tube. International Journal of Molecular Sciences 22(8), 2021

A role for rhoB in the delamination of neural crest cells from the dorsal neural tube. Development 125(24): 5055-5067, 1998

Cadherin interplay during neural crest segregation from the non-neural ectoderm and neural tube in the early chick embryo. Developmental Dynamics: An Official Publication of the American Association of Anatomists 246(7): 550-565, 2017

Observation of primary cells of the neural crest in dorsal mesodermic space adjacent to the neural tube. Bulletin de l'Association des Anatomistes 80(251): 52, 1996

Requirement of a neural tube signal for the differentiation of neural crest cells into dorsal root ganglia. Developmental Biology 116(2): 451-466, 1986

High frequency of cephalic neural crest cells shows coexistence of neurogenic, melanogenic, and osteogenic differentiation capacities. Proceedings of the National Academy of Sciences of the United States of America 106(22): 8947-8952, 2009

TWIST1 interacts with β/δ-catenins during neural tube development and regulates fate transition in cranial neural crest cells. Development 149(15), 2022

Molecular identification of distinct neurogenic and melanogenic neural crest sublineages. Development 130(2): 321-330, 2003

Neural crest cell lineage segregation in the mouse neural tube. Development 131(24): 6153-6162, 2004

Migration and differentiation of neural crest and ventral neural tube cells in vitro: implications for in vitro and in vivo studies of the neural crest. Journal of Neuroscience: the Official Journal of the Society for Neuroscience 8(3): 1001-1015, 1988

Fate map and morphogenesis of presumptive neural crest and dorsal neural tube. Developmental Biology 330(2): 221-236, 2009

Cytotactin expression in somites after dorsal neural tube and neural crest ablation in chicken embryos. Proceedings of the National Academy of Sciences of the United States of America 88(15): 6398-6402, 1991

NOTCH signaling regulates neural crest segregation at the neural plate-epidermal ectoderm boundary in avian embryo. Development Growth and Differentiation 43(Suppl): S32, 2001