+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A dynamical model of genetic networks for cell differentiation



A dynamical model of genetic networks for cell differentiation



Plos One 6(3): E17703



A mathematical model is proposed which is able to describe the most important features of cell differentiation, without requiring specific detailed assumptions concerning the interactions which drive the phenomenon. On the contrary, cell differentiation is described here as an emergent property of a generic model of the underlying gene regulatory network, and it can therefore be applied to a variety of different organisms. The model points to a peculiar role of cellular noise in differentiation and leads to non trivial predictions which could be subject to experimental testing. Moreover, a single model proves able to describe several different phenomena observed in various differentiation processes.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 051130762

Download citation: RISBibTeXText

PMID: 21464974


Related references

Spatially organized dynamical states in chemical oscillator networks: synchronization, dynamical differentiation, and chimera patterns. Plos One 8(11): E80586, 2014

Phenotypic and dynamical transitions in model genetic networks. II. Application to the evolution of segmentation mechanisms. Evolution and Development 3(2): 95-103, 2001

Phenotypic and dynamical transitions in model genetic networks. I. Emergence of patterns and genotype-phenotype relationships. Evolution and Development 3(2): 84-94, 2001

Abstract genetic representation of dynamical neural networks using Kauffman networks. Artificial Life 3(2): 67-80, 1997

On the dynamical properties of a model of cell differentiation. Eurasip Journal on Bioinformatics and Systems Biology 2013(1): 4, 2013

Deconstruction and dynamical robustness of regulatory networks: application to the yeast cell cycle networks. Bulletin of Mathematical Biology 75(6): 939-966, 2014

Genetic "code": representations and dynamical models of genetic components and networks. Annual Review of Genomics and Human Genetics 3: 341-369, 2002

Identification of genetic networks involved in the cell growth arrest and differentiation of a rat astrocyte cell line RCG-12. Journal of Cellular Biochemistry 102(6): 1472-1485, 2007

Genetic and epigenetic networks controlling T helper 1 cell differentiation. Immunology 127(2): 155-162, 2009

Qualitative dynamical analysis of genetic regulatory networks. Journal of Cellular Biochemistry Supplement 0(19A): 344, 1995

Dynamical properties of model communication networks. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 66(2 Pt 2): 026704, 2002

Bistable responses in bacterial genetic networks: designs and dynamical consequences. Mathematical Biosciences 231(1): 76-89, 2012

Modeling genetic networks and their evolution: a complex dynamical systems perspective. Biological Chemistry 382(9): 1289-1299, 2001

Flower development as an interplay between dynamical physical fields and genetic networks. Plos One 5(10): E13523, 2011

Modeling pathways of differentiation in genetic regulatory networks with Boolean networks. Complexity 11(1): 52-60, 2005