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A highly convergent synthesis of tricyclic N-heterocycles coupling an Ugi reaction with a tandem S (N) 2'-Heck double cyclization

Riva, R.; Banfi, L.; Basso, A.; Cerulli, V.; Guanti, G.; Pani, M.

Journal of Organic Chemistry 75(15): 5134-5143

2010


ISSN/ISBN: 1520-6904
PMID: 20575586
DOI: 10.1021/jo100859y
Accession: 051145588

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A small library of natural product-like compounds has been assembled by coupling an Ugi multicomponent reaction with two postcondensation transformations, carried out in one-pot fashion: a S(N)2' cyclization followed by an intramolecular Heck reaction.

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