+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A meta-analysis of large randomized trials for mid-term major cardio- and cerebrovascular events following off-pump versus on-pump coronary artery bypass grafting



A meta-analysis of large randomized trials for mid-term major cardio- and cerebrovascular events following off-pump versus on-pump coronary artery bypass grafting



Interactive Cardiovascular and Thoracic Surgery 18(4): 522-524



To determine whether off-pump coronary artery bypass grafting (CABG) increases mid-term major adverse cardiovascular (and cerebrovascular) events MACCE over on-pump CABG, we performed a meta-analysis of exclusive large randomized controlled trials (RCTs). Databases including MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials were searched through October 2013 using Web-based search engines (PubMed and OVID). Eligible studies were RCTs of off-pump vs on-pump CABG enrolling >100 patients in each procedure and reporting MACCE at the time of >1 year follow-up. Mixed-effects meta-regression analyses were performed to determine whether the effects of off-pump CABG on MACCE were modulated by the prespecified factors. Eight RCTs enrolling 10 954 patients were identified and included. A pooled analysis demonstrated no statistically significant difference in off-pump and on-pump CABG (hazard ratio, 1.10; 95% confidence interval, 0.93-1.29; P = 0.27). In general, exclusion of any single study from the analysis did not substantially alter the overall result of our analysis. There was no evidence of significant publication bias. Meta-regression coefficients were not statistically significant for mean age, proportion of men and that of diabetes. In conclusion, off-pump CABG appears not to increase mid-term MACCE over on-pump CABG.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 051158085

Download citation: RISBibTeXText

PMID: 24381313

DOI: 10.1093/icvts/ivt536


Related references

Short-term and Long-term Postoperative Safety of Off-Pump versus On-Pump Coronary Artery Bypass Grafting for Coronary Heart Disease: A Meta-analysis for Randomized Controlled Trials. Thoracic and Cardiovascular Surgeon 63(4): 319-327, 2016

A meta-analysis of randomized trials for repeat revascularization following off-pump versus on-pump coronary artery bypass grafting. Interactive Cardiovascular and Thoracic Surgery 17(5): 878-880, 2013

A meta-analysis of ≥5-year mortality in randomized controlled trials of off-pump versus on-pump coronary artery bypass grafting. Journal of Cardiac Surgery 33(11): 716-724, 2018

Incidence of atrial fibrillation after off-pump versus on-pump coronary artery bypass grafting: A meta-analysis of randomized clinical trials and propensity score matching trials. Journal of Huazhong University of Science and Technology. Medical Sciences 37(6): 956-964, 2017

Comparison of renal outcomes in off-pump versus on-pump coronary artery bypass grafting: A systematic review and meta-analysis of randomized controlled trials. Nephrology 20(10): 727-735, 2015

Cerebrovascular Events After No-Touch Off-Pump Coronary Artery Bypass Grafting, Conventional Side-Clamp Off-Pump Coronary Artery Bypass, and Proximal Anastomotic Devices: A Meta-Analysis. Journal of the American Heart Association 5(2):, 2016

Current evidence of coronary artery bypass grafting off-pump versus on-pump: a systematic review with meta-analysis of over 16,900 patients investigated in randomized controlled trials†. European Journal of Cardio-Thoracic Surgery 49(4): 1031-41; Discussion 1041, 2016

Inhalation versus intravenous anaesthesia for adults undergoing on-pump or off-pump coronary artery bypass grafting: A systematic review and meta-analysis of randomized controlled trials. Journal of Clinical Anesthesia 40: 127-138, 2017

Lower graft patency after off-pump than on-pump coronary artery bypass grafting: an updated meta-analysis of randomized trials. Journal of Thoracic and Cardiovascular Surgery 140(3): E45-E47, 2010

Off-pump coronary artery bypass grafting does not increase the 1-year mortality compared to on-pump: a meta-analysis of randomized controlled trials. International Journal of Cardiology 169(5): E93-E95, 2013

Off-pump versus on-pump coronary artery bypass: meta-analysis of currently available randomized trials. Annals of Thoracic Surgery 76(1): 37-40, 2003

Off-pump surgery does not reduce stroke, compared with results of on-pump coronary artery bypass grafting: a meta-analysis of randomized clinical trials. Journal of Thoracic and Cardiovascular Surgery 134(4): 1059-1060, 2007

Off-pump versus on-pump coronary artery bypass surgery: meta-analysis and meta-regression of 13,524 patients from randomized trials. Revista Brasileira de Cirurgia Cardiovascular 27(4): 631-641, 2012

Miniaturized extracorporeal circulation versus off-pump coronary artery bypass grafting: a meta-analysis of randomized controlled trials. International Journal of Surgery 14: 96, 2015

Meta-analysis of randomized controlled trials of cognitive decline after on-pump versus off-pump coronary artery bypass graft surgery. Journal of Thoracic and Cardiovascular Surgery 135(6): 1400-1; Author Reply 1401, 2008