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A randomized single-blind controlled clinical trial of tacrolimus mouth rinse on erosive oral lichen planus



A randomized single-blind controlled clinical trial of tacrolimus mouth rinse on erosive oral lichen planus



Shanghai Kou Qiang Yi Xue 22(6): 708-710



To evaluate the efficacy and safety of tacrolimus mouth rinse on the treatment of erosive and ulcerative oral lichen planus (OLP). A randomized single-blind open trial of tacrolimus mouth rinse with dexamethasone as control was designed. The VAS and REU scoring system was utilized to compare the signs and symptoms. The scores and therapeutic effects were analyzed with SPSS 17.0 software package. There was no significant difference in effective rate between the treatment group and control group (X(2)=0.295,0.413, P>0.01) at 4-week and 12-week after treatment. There was significant difference in REU scores between the 2 groups (P<0.01) 4 weeks after treatment. Tacrolimus mouth rinse effects quickly and is worthy of application in the treatment of erosive and ulcerative OLP.

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Accession: 051229308

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PMID: 24469140


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