+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A risperidone-induced prolactinoma resolved when a woman with schizoaffective disorder switched to ziprasidone: a case report



A risperidone-induced prolactinoma resolved when a woman with schizoaffective disorder switched to ziprasidone: a case report



Innovations in Clinical Neuroscience 9(9): 21-24



Antipsychotic drug therapy, e.g., risperidone, can be associated with endocrine abnormalities, including an increase in serum prolactin level (sPrl) due to a drug-induced benign pituitary tumor (prolactinoma). A few case reports have noted a resolution of hyperprolactinemia and prolactinoma after cessation of risperidone treatment. We report a similar finding for a woman with schizoaffective disorder, manic type.Due to a neurological disorder involving the tongue (tardive dyskinesia), a woman with schizoaffective disorder switched from 50mg thioridazine after 21 years to 2mg of risperidone at bedtime for 10 years. Elevated sPrl was noted in June and August 2005 (83.8 and 100.1µg/L; normal: 3.4-24.1µg/L) and a cranial magnetic resonance imaging scan showed evidence of a small area of decreased signal in the pituitary gland consistent with a microadenoma. The subject transitioned slowly to ziprasidone and off risperidone in October and November of 2005. The prolactinoma completely resolved with the switch to ziprasidone. It is recommended that sPrl be measured annually in patients taking antipsychotic drugs to test for any indication of pituitary prolactinoma that could suggest the need to switch the primary treatment to another drug.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 051244811

Download citation: RISBibTeXText

PMID: 23074699


Related references

Regarding "A Risperidone-induced Prolactinoma Resolved When A Woman with Schizoaffective Disorder Switched to Ziprasidone: A Case Report". Innovations in Clinical Neuroscience 10(2): 12-16, 2013

Risperidone as monotherapy for a patient with obsessive compulsive disorder comorbid with schizoaffective disorder: a case report. Clinical Neuropharmacology 38(3): 114-116, 2016

Efficacy and tolerability of ziprasidone versus risperidone in patients with acute exacerbation of schizophrenia or schizoaffective disorder: an 8-week, double-blind, multicenter trial. Journal of Clinical Psychiatry 65(12): 1624-1633, 2004

Efficacy and Tolerability of Ziprasidone Versus Risperidone in Patients With Acute Exacerbation of Schizophrenia or Schizoaffective Disorder: An 8-Week, Double-Blind, Multicenter Trial. Yearbook of Psychiatry and Applied Mental Health 2006: 225-226, 2006

A case report of schizoaffective disorder with ritualistic behaviors and catatonic stupor: successful treatment by risperidone and modified electroconvulsive therapy. Bmc Psychiatry 18(1): 67, 2018

A Case of Sleepwalking With Sleep-Related Eating Associated With Ziprasidone Therapy in a Patient With Schizoaffective Disorder. Journal of Clinical Psychopharmacology 36(4): 393-394, 2016

Switching from quetiapine to ziprasidone: a sixteen-week, open-label, multicenter study evaluating the effectiveness and safety of ziprasidone in outpatient subjects with schizophrenia or schizoaffective disorder. Journal of Psychiatric Practice 17(2): 100-109, 2011

Efficacy of risperidone treatment for psychoses associated with schizophrenia, schizoaffective disorder, bipolar disorder, or senile dementia in 11 geriatric patients: a case series. Journal of Clinical Psychiatry 56(11): 514-518, 1995

Major depressive disorder induced by prolactinoma--a case report. General Hospital Psychiatry 36(1): 125.E1-2, 2014

Effect of risperidone on prolactinoma--a case report. Pharmacopsychiatry 37(1): 41-42, 2004

Benefits of ziprasidone in stable outpatient schizophrenics switched from conventional antipsychotics, olanzapine, or risperidone. European Neuropsychopharmacology 10(Suppl. 3): S289, 2000

Case report of valproate-induced hypothermia in a patient with schizoaffective disorder. Primary Care Companion to the Journal of Clinical Psychiatry 11(6): 363-364, 2009

Lamotrigine-induced neutropenia in a woman with schizoaffective disorder. Primary Care Companion to the Journal of Clinical Psychiatry 9(6): 471-472, 2007

Mania induced by quetiapine in patients with schizoaffective disorder, depressive type: a case report. Revista Brasileira de Psiquiatria 31(3): 286-287, 2009

Ziprasidone: a review of its use in schizophrenia and schizoaffective disorder. Drugs 62(8): 1217-1251, 2002