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A sequential metal-catalyzed C-N bond formation in the synthesis of 2-amido-indoles



A sequential metal-catalyzed C-N bond formation in the synthesis of 2-amido-indoles



Organic Letters 10(19): 4275-4278



A sequential metal-catalyzed C-N bond formation employing ortho-haloaryl acetylenic bromides is described. The initial amidation is highly selective for C (sp)-N bond formation, leading to o-haloaryl-substituted ynamides that can be useful building blocks, while the overall sequence provides a facile construction of 2-amido-indoles.

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Accession: 051249905

Download citation: RISBibTeXText

PMID: 18754591

DOI: 10.1021/ol801711p


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