+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder

A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder

Psychological Medicine 39(2): 179-195

A systematic review of all reported incidence and prevalence studies of population rates of subclinical psychotic experiences reveals a median prevalence rate of around 5% and a median incidence rate of around 3%. A meta-analysis of risk factors reveals associations with developmental stage, child and adult social adversity, psychoactive drug use, and also male sex and migrant status. The small difference between prevalence and incidence rates, together with data from follow-up studies, indicates that approximately 75-90% of developmental psychotic experiences are transitory and disappear over time. There is evidence, however, that transitory developmental expression of psychosis (psychosis proneness) may become abnormally persistent (persistence) and subsequently clinically relevant (impairment), depending on the degree of environmental risk the person is additionally exposed to. The psychosis proneness-persistence-impairment model considers genetic background factors impacting on a broadly distributed and transitory population expression of psychosis during development, poor prognosis of which, in terms of persistence and clinical need, is predicted by environmental exposure interacting with genetic risk.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 051271476

Download citation: RISBibTeXText

PMID: 18606047

DOI: 10.1017/s0033291708003814

Related references

A psychosis proneness-persistence-impairment model of psychotic disorders. Tijdschrift Voor Psychiatrie 50 Spec No.: 77-83, 2008

Does normal developmental expression of psychosis combine with environmental risk to cause persistence of psychosis? A psychosis proneness-persistence model. Psychological Medicine 37(4): 513-527, 2007

Does Eysenck's personality model capture psychosis-proneness? A systematic review and meta-analysis. Personality and Individual Differences 143: 155-164, 2019

The psychosis proneness: psychosis persistence model as an explanation for the association between urbanicity and psychosis. Epidemiologia E Psichiatria Sociale 15(4): 252-257, 2006

Risk of Psychosis in Recurrent Episodes of Psychotic and Nonpsychotic Major Depressive Disorder: A Systematic Review and Meta-Analysis. American Journal of Psychiatry 175(9): 897-904, 2018

An updated and conservative systematic review and meta-analysis of epidemiological evidence on psychotic experiences in children and adults: on the pathway from proneness to persistence to dimensional expression across mental disorders. Psychological Medicine 43(6): 1133-1149, 2013

Attenuated psychotic symptom interventions in youth at risk of psychosis: A systematic review and meta-analysis. Early Intervention in Psychiatry 13(1): 3-17, 2019

Duration of untreated psychosis and neurocognitive functioning in first-episode psychosis: a systematic review and meta-analysis. Psychological Medicine 48(10): 1592-1607, 2018

Theory of mind impairments in first-episode psychosis, individuals at ultra-high risk for psychosis and in first-degree relatives of schizophrenia: systematic review and meta-analysis. Schizophrenia Research 144(1-3): 31-36, 2013

Childhood abuse in the etiological continuum underlying psychosis from first-episode psychosis to psychotic experiences. European Psychiatry 30(1): 38-42, 2015

Protocol for a systematic review and meta-analysis of cognitive-behavioural therapy for social anxiety disorder in psychosis. Systematic Reviews 3: 62, 2014

Developmental Coordination Disorder Plus Oculomotor and Visuospatial Impairment as Neurodevelopmental Heralds of Psychosis Proneness. Clinical Schizophrenia and Related Psychoses 2016:, 2016

Risk of Postpartum Relapse in Bipolar Disorder and Postpartum Psychosis: A Systematic Review and Meta-Analysis. American Journal of Psychiatry 173(2): 117-127, 2016

Voice identity discrimination and hallucination-proneness in healthy young adults: a further challenge to the continuum model of psychosis?. Cognitive Neuropsychiatry 19(4): 305-318, 2014

Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology. Psychological Medicine 45(11): 2389-2401, 2015