+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

ADAM33 gene polymorphisms and mortality. A prospective cohort study

ADAM33 gene polymorphisms and mortality. A prospective cohort study

Plos One 8(7): E67768-E67768

The ADAM33 gene is associated with the pathophysiology of Chronic Obstructive Pulmonary Disease (COPD) and atherosclerosis. In this study we investigated all-cause, COPD and cardiovascular mortality, in relation to single nucleotide polymorphisms (SNPs) in ADAM33 (Q_1, S_1, S_2, T_1 and T_2) that were genotyped in 1,390 subjects from the Vlagtwedde/Vlaardingen cohort. Participants were examined at entry in 1989/1990 and followed up till evaluation of the vital status on December 31(st), 2008. Using Cox proportional hazards regression we estimated the risk of the SNPs in relation to mortality, adjusting for gender, age, FEV1, height, place of residence and packyears of smoking. Additionally, we performed stratified analyses according to gender and smoking habits. After 18 years, 284 (20.4%) subjects had died (107 due to cardiovascular disease and 20 due to COPD). Individuals homozygous for the minor allele of SNP T_2 had an increased risk of all-cause and cardiovascular mortality compared to wild types: hazard ratio 3.6 (95% confidence interval 2.0 to 6.7) and 3.4 (1.2 to 9.5) respectively. Individuals homozygous for the minor allele of S_1, S_2, T_2 or Q_1 had a significantly increased risk of COPD mortality. In stratified analyses the risk of all-cause mortality associated with SNP T_2 did not change: females 3.5 (1.5 to 8.3), males 3.1 (1.2 to 7.6), never smokers 3.8 (0.9 to 16.3), ever smokers 3.6 (1.8 to 7.2). This study shows for the first time that ADAM33 is a pleiotropic gene that is associated with all-cause, COPD and cardiovascular mortality, independent of potential confounders.

(PDF same-day service: $19.90)

Accession: 051292571

Download citation: RISBibTeXText

PMID: 23861802

DOI: 10.1371/journal.pone.0067768

Related references

ADAM33 polymorphisms predict early-life lung function A population based cohort Study. American Journal of Human Genetics 73(5): 209, November, 2003

Hormone treatment, estrogen receptor polymorphisms and mortality: a prospective cohort study. Plos One 7(3): E34112-E34112, 2012

Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study. Bmc Medical Genetics 10(): 103-103, 2009

An ADAM33 polymorphism associates with progression of preschool wheeze into childhood asthma: a prospective case-control study with replication in a birth cohort study. Plos One 10(3): E0119349-E0119349, 2016

Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study. Clinical Infectious Diseases 54(4): 502-510, 2012

CYBA Gene Polymorphisms and Adverse Outcomes in Acute Kidney Injury: A Prospective Cohort Study. Nephron Extra 1(1): 112-123, 2011

ABCC2 transporter gene polymorphisms, diet and risk of colorectal cancer: a Danish prospective cohort study. Scandinavian Journal of Gastroenterology 47(5): 572-574, 2012

Interleukin-6 gene polymorphisms correlate with the progression of nephropathy in Chinese patients with type 2 diabetes: A prospective cohort study. Diabetes Research and Clinical Practice 120(): 15-23, 2016

Passive smoking, metabolic gene polymorphisms, and infant birth weight in a prospective cohort study of Chinese women. American Journal of Epidemiology 166(3): 313-322, 2007

Analysis of silent information regulator 1 (SIRT1) gene polymorphisms in antituberculosis- drug-induced hepatotoxicity in a prospective cohort study. International Journal of Clinical Pharmacology and Therapeutics 54(10): 775-781, 2016

The influence of iron status and genetic polymorphisms in the HFE gene on the risk for postoperative complications after bariatric surgery: a prospective cohort study in 1,064 patients. Patient Safety in Surgery 5(1): 1-1, 2011

Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study. Diabetes 59(11): 2945-2948, 2010

Identification of novel polymorphisms in the Adam33 gene. Journal of Human Genetics 48(5): 278-281, 2003

Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study. Journal of Internal Medicine 263(4): 376-385, 2007

Interactions between diet, lifestyle and IL10, IL1B, and PTGS2/COX-2 gene polymorphisms in relation to risk of colorectal cancer in a prospective Danish case-cohort study. Plos One 8(10): E78366-E78366, 2015