EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Achieving glycemic goals with addition of incretin-based therapies to insulin in patients with type 2 diabetes mellitus


Achieving glycemic goals with addition of incretin-based therapies to insulin in patients with type 2 diabetes mellitus



American Journal of the Medical Sciences 347(6): 491-501



ISSN/ISBN: 0002-9629

PMID: 24469234

DOI: 10.1097/maj.0000000000000202

As type 2 diabetes mellitus progresses, multiple antihyperglycemic agents are needed to maintain adequate glycemic control. Consensus guidelines recommend combining agents with complementary mechanisms of action. Given that hypoglycemic events increase the risk of cardiovascular disease and that weight gain affects mortality in obese individuals, it is important to control hyperglycemia without inducing hypoglycemia or weight gain. Peer-reviewed clinical trial data from patients requiring insulin-containing combination therapy suggest that insulin may be more effective at controlling hyperglycemia when given with appropriate combination therapy, but insulin is associated with weight gain and hypoglycemia. Some agents should not be combined with insulin because of associated weight gain and edema (ie, thiazolidinediones) or hypoglycemia (ie, sulfonylureas). Conversely, the lack of weight gain and hypoglycemia associated with metformin, glucagon-like peptide-1 agonists and dipeptidyl peptidase-4 inhibitors and suppression of glucagon secretion by both classes of incretin-based therapies suggest that these agents are well suited to combination therapy with insulin.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 051332329

Download citation: RISBibTeXText

Related references

Distinguishing among incretin-based therapies. Pathophysiology of type 2 diabetes mellitus: potential role of incretin-based therapies. Journal of Family Practice 59(9 Suppl 1): S5-S9, 2010

Incretin-based therapies for type 2 diabetes mellitus: effects on insulin resistance. Current Diabetes Reviews 9(5): 412-417, 2013

Retrospective Study on the Impact of Adherence in Achieving Glycemic Goals in Type 2 Diabetes Mellitus Patients Receiving Canagliflozin. Advances in Therapy 34(4): 937-953, 2017

Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort database. Diabetes Care 33(8): 1759-1765, 2010

Beyond glycemic control in diabetes mellitus: effects of incretin-based therapies on bone metabolism. Frontiers in Endocrinology 4: 73, 2013

Efficacy and safety of incretin-based therapies in patients with type 2 diabetes mellitus. American Journal of Medicine 122(6 Suppl): S11-S24, 2009

Differentiating among incretin-based therapies in the management of patients with type 2 diabetes mellitus. Diabetology and Metabolic Syndrome 4(1): 8, 2012

Efficacy and safety of incretin-based therapies in patients with type 2 diabetes mellitus. European Journal of Internal Medicine 20(Suppl): S309-S318, 2009

Are patients on basal insulin attaining glycemic targets? Characteristics and goal achievement of patients with type 2 diabetes mellitus treated with basal insulin and physician-perceived barriers to achieving glycemic targets. Diabetes Research and Clinical Practice 121: 17-26, 2016

Novel incretin-based agents and practical regimens to meet needs and treatment goals of patients with type 2 diabetes mellitus. Journal of the American Osteopathic Association 111(7 Suppl 5): S20-S30, 2011

The intersection of safety and adherence: new incretin-based therapies in patients with type 2 diabetes mellitus. PharmacoTherapy 29(12 Pt 2): 55s-67s, 2009

Approaches to rapid acting insulin intensification in patients with type 2 diabetes mellitus not achieving glycemic targets. Annals of Medicine 50(6): 453-460, 2018

Patient-reported outcomes in trials of incretin-based therapies in patients with type 2 diabetes mellitus. Diabetes Obesity and Metabolism 14(10): 882-892, 2012

Safety and Efficacy of Incretin-Based Therapies in Patients With Type 2 Diabetes Mellitus and CKD: A Systematic Review and Meta-analysis. American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation 68(5): 733-742, 2016

Addition of insulin aspart with basal insulin is associated with improved glycemic control in Indian patients with uncontrolled type 2 diabetes mellitus: the A1chieve observational study. Journal of the Association of Physicians of India 61(1 Suppl): 24-27, 2013