Activity of anidulafungin in a murine model of Candida krusei infection: evaluation of mortality and disease burden by quantitative tissue cultures and measurement of serum (1,3) -beta-D-glucan levels

Ostrosky-Zeichner, L.; Paetznick, V.L.; Rodriguez, J.; Chen, E.; Sheehan, D.J.

Antimicrobial Agents and ChemoTherapy 53(4): 1639-1641

2009


ISSN/ISBN: 1098-6596
PMID: 19139291
DOI: 10.1128/aac.00955-08
Accession: 051348334

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Abstract
Experience with anidulafungin against Candida krusei is limited. Immunosuppressed mice were injected with 1.3 x 10(7) to 1.5 x 10(7) CFU of C. krusei. Animals were treated with saline, 40 mg/kg fluconazole, 1 mg/kg amphotericin B, or 10 and 20 mg/kg anidulafungin for 5 days. Anidulafungin improved survival and significantly reduced the number of CFU/g in kidneys and serum beta-glucan levels.