+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Acute renal failure as the presenting feature of leukaemic infiltration in chronic lymphocytic leukaemia



Acute renal failure as the presenting feature of leukaemic infiltration in chronic lymphocytic leukaemia



Clinical and Experimental Nephrology 13(2): 179-181



Chronic lymphocytic leukaemia (CLL) is a neoplastic condition of B cells which commonly affects the lymph nodes, liver, spleen and bone marrow. Leukaemic involvement of the kidney is also relatively common in CLL, but characteristically is not associated with renal impairment. Our report describes a patient who developed acute renal failure as the initial presenting feature of CLL. The renal failure was subsequently found to be due to direct leukaemic infiltration. Treatment with chlorambucil and prednisolone resulted in stabilisation of the renal function for approximately 1 year prior to the need for long-term haemodialysis. Leukaemic infiltration of kidney should always be considered when a patient with CLL presents with renal impairment, regardless of the clinical stage, as the renal failure often responds well to chemotherapy.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 051363438

Download citation: RISBibTeXText

PMID: 19255826

DOI: 10.1007/s10157-009-0129-y


Related references

Acute Renal Failure due to Leukaemic Infiltration in Chronic Lymphocytic Leukaemia. Case Reports in Medicine 2015: 469136, 2015

Acute renal failure due to leukaemic infiltration in chronic lymphocytic leukaemia: case report. International Journal of Clinical Practice. Supplement 2005(147): 53-55, 2005

Renal failure due to leukaemic infiltration in chronic lymphocytic leukaemia. Nephrology Dialysis Transplantation 5(12): 1051-1052, 1990

Renal failure caused by leukaemic infiltration in chronic lymphocytic leukaemia. Journal of Clinical Pathology 46(12): 1131-1133, 1993

Chronic lymphocytic leukaemia presenting as renal failure with lymphocytic infiltration of the kidneys. Netherlands Journal of Medicine 41(1-2): 64-67, 1992

Reversible renal failure due to renal infiltration and associated tubulointerstitial disease in chronic lymphocytic leukaemia. Nephrology Dialysis Transplantation 5(8): 616-618, 1990

Reversible Renal Failure Due to Renal Infiltration and Associated Tubulointerstitial Disease in Chronic Lymphocytic Leukaemia. Nephrology Dialysis Transplantation 5(8): 616-618, 1990

Reversible renal failure due to specific infiltration of the kidney in chronic lymphocytic leukaemia. Nephrology Dialysis Transplantation 13(6): 1550-1552, 1998

Leukaemic infiltration of gall bladder - unusual presentation of occult chronic lymphocytic leukaemia. Journal of Surgical Case Reports 2011(1): 7, 2011

Acute renal failure with chronic lymphocytic leukaemia. Postgraduate Medical Journal 72(854): 763-765, 1996

Acute renal failure and chronic lymphocytic leukaemia. Nephrology Dialysis Transplantation 23(2): 770-771, 2008

Leukaemic myocardial infiltration presenting as acute heart failure. European Heart Journal Cardiovascular Imaging 16(4): 460, 2015

Alemtuzumab-induced remission of both severe paraneoplastic pemphigus and leukaemic bone marrow infiltration in a case of treatment-resistant B-cell chronic lymphocytic leukaemia. European Journal of Haematology 73(3): 206-209, 2004

Progressive multifocal leukoencephalopathy as the presenting feature of chronic lymphocytic leukaemia. British Journal of Haematology 167(4): 570-571, 2014

Cytomegalovirus-associated haemophagocytic syndrome and acute renal failure in a patient with chronic lymphocytic leukaemia. Ugeskrift for Laeger 176(25a):, 2014