Section 52
Chapter 51,387

Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB (1) cannabinoid receptors

Mateos, B.; Borcel, E.; Loriga, R.; Luesu, W.; Bini, V.; Llorente, R.; Castelli, M.P.; Viveros, M-P.

Journal of Psychopharmacology 25(12): 1676-1690


ISSN/ISBN: 0269-8811
PMID: 20562169
DOI: 10.1177/0269881110370503
Accession: 051386184

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We have analysed the long-term effects of adolescent (postnatal day 28–43) exposure of male and female rats to nicotine (NIC, 1.4 mg/kg/day) and/or the cannabinoid agonist CP 55,94 (CP, .4 mg/kg/day) on the following parameters measured in the adulthood: (1) the memory ability evaluated in the object location task (OL) and in the novel object test (NOT); the anxiety-like behaviour in the elevated plus maze; and nicotinic and CB1 cannabinoid receptors in cingulated cortex and hippocampus. In the OL, all pharmacological treatments induced significant decreases in the DI of females, whereas no significant effects were found among males. In the NOT, NIC-treated females showed a significantly reduced DI, whereas the effect of the cannabinoid agonist (a decrease in the DI) was only significant in males. The anxiety-related behaviour was not changed by any drug. Both, nicotine and cannabinoid treatments induced a long-lasting increase in CB1 receptor activity (CP-stimulated GTPS binding) in male rats, and the nicotine treatment also induced a decrease in nicotinic receptor density in the prefrontal cortex of females. The results show gender-dependent harmful effects of both drugs and long-lasting changes in CB1 and nicotinic receptors.

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